Pajeロン Injection 1 gram (Cefazedone Sodium)

Adult administration

For cefazolin sodium in cases of infection caused by gram-positive bacteria, 1-2 g (potency) should be administered by intravenous injection in divided doses 2-3 times per day. For infections caused by gram-negative bacteria, 3-4 g (potency) should be administered daily in divided doses of 2-3 times. In life-threatening infections or infections due to moderately susceptible bacteria, the dose may be increased up to 6 g (potency) daily. When administering intravenously, dissolve approximately 1 g (potency) in 5 mL of injection water and inject slowly over 2-3 minutes.

This medication should not be used in patients with hypersensitivity to cephalosporin antibiotics. It should especially be avoided in premature infants and newborns. Caution is required for pregnant women in the first three months of pregnancy or patients with renal and liver function issues. Patients with hemophilia or thrombocytopenia, as well as those with gastrointestinal ulcers, should also be monitored closely. Patients who have difficulty with oral intake or are receiving parenteral nutrition, elderly patients, and those in poor general condition should be monitored closely for signs of vitamin K deficiency. When using this medication, mild allergic reactions such as temporary headache, dizziness, and nausea may occur, and rarely serious allergic reactions like skin rashes, fever, or anaphylaxis may occur, so careful observation is necessary. Liver function test results may temporarily rise, and there may be transient leukopenia. Severe intestinal inflammation symptoms like pseudomembranous colitis may occur, so if abdominal pain or frequent diarrhea occurs, administration should be stopped immediately. Respiratory symptoms such as fever, cough, and difficulty breathing may rarely appear, and in these cases, administration should be halted, and appropriate treatment should be received. Disruptions in flora such as stomatitis or candidiasis can occur, and symptoms of vitamin K or B-complex deficiencies may rarely present, requiring caution. To prevent the occurrence of resistant bacteria, it is important to use this medication only for the minimum period necessary according to susceptibility testing. Adequate history-taking and skin reaction testing prior to use is advisable to reduce the risk of allergic reactions or shock. After administration, the patient should be closely observed in a stable condition, and preparations for emergency treatment should be made in case of shock. When used with other antibiotics or diuretics that may stress the kidneys, renal function should be closely monitored. When used concurrently with oral anticoagulants, there is a risk of bleeding, so blood status should be carefully checked. If the patient is breastfeeding, caution should be exercised as this medication may be excreted in small amounts in breast milk. Finally, this medication should not be mixed with other antibiotics in a syringe prior to injection.

Serious side effects

Anaphylaxis (severe allergic reaction), fever with skin rash, blistering, skin peeling, pain in oral/ocular mucosa (severe skin adverse reactions), respiratory difficulties, breathing anomalies associated with cough + fever, severe colitis, interstitial pneumonia, PIE syndrome, occurrence of shock, severe colitis with blood in stool.

Mild side effects

Mild headache, dizziness, nausea, skin rash, fever, elevated AL-P, GOT, GPT, transient leukopenia, vomiting, loss of appetite, abdominal pain, frequent diarrhea, stomatitis, candidiasis, vitamin K deficiency symptoms (e.g., hypoprothrombinemia, tendency to bleed), and vitamin B-complex deficiency symptoms (e.g., glossitis, stomatitis, loss of appetite, neuritis).

This medication should be stored in a sealed container at room temperature between 1 to 30 degrees Celsius. Storing it this way maintains the drug's efficacy and allows for safe use.

Appearance

A colorless transparent vial filled with a white to yellowish powder

Package unit

10 vials (1g/vial x 10)