Jeil Pharmaceutical Neostigmine Methylsulfate Injection

Adult administration

Administer 0.25–0.5 mg of Neostigmine Methylsulfate by intramuscular or subcutaneous injection 1 to 3 times a day. Do not exceed 5 mg per day. Adjust dosage appropriately according to age and symptoms.

This medication is an ampoule injection, and there is a risk of glass particles being present, so care must be taken when opening the container. Special caution is required when administering to children or the elderly. This medication contains benzyl alcohol as an excipient, which can cause life-threatening respiratory issues in premature infants, and should not be used in neonates or premature infants. Patients with gastrointestinal or urinary tract obstruction, those with an allergy to this medication, patients with vagal nerve tension syndrome, and those currently on certain muscle relaxants should not use this drug. Patients with bronchial asthma, hyperthyroidism, coronary occlusion, bradycardia, peptic ulcers, epilepsy, or Parkinson's syndrome should use this medication with particular caution. Using this medication may cause symptoms such as abdominal pain, diarrhea, excessive sweating, increased saliva production, constricted pupils, and muscle cramps, and should these symptoms occur, medical personnel should be notified immediately. Blood pressure may decrease, heart rate may slow down or speed up, and bronchospasm or increased airway secretion may also occur. There may also be hypersensitivity reactions while using this drug; therefore, if allergic symptoms occur, administration should be stopped. Myasthenia gravis patients may experience aggravated symptoms from this medication and may face critical situations such as difficulty breathing or swallowing, thus should be observed closely. When combined with other medications, particularly depolarizing muscle relaxants or cholinergic agents, interactions may occur leading to increased side effects, so caution is necessary. Women who are pregnant or may become pregnant should avoid using this medication, and elderly patients may require dosage adjustments due to decreased physical function. In cases of overdose, severe symptoms such as abdominal pain, diarrhea, excessive salivation, and muscle cramps may occur, and administration should be stopped immediately, followed by medical treatment.

Serious side effects

Respiratory distress, respiratory distress, major respiratory issues classified as severe respiratory problems

Mild side effects

• Abdominal pain
• diarrhea
• sweating
• excessive salivation
• miosis
• muscle twitching
• hypotension
• bradycardia
• tachycardia
• bronchospasm

This medication may be sensitive to light, therefore it should be stored in an opaque container to prevent light exposure. Additionally, it should be kept in a sealed container to avoid contact with air and maintain its efficacy.

Appearance

Brown ampoule containing a colorless transparent liquid

Package unit

50 ampoules/box [1 milliliter/ampoule * 50]