Toburex Injection (Dobutamine Hydrochloride)

Adult administration

Inject 2.5-10 µg/min per kg body weight of dobutamine intravenously. In rare cases, infusion rates of 40 µg/min per kg body weight may be necessary to achieve satisfactory effects. The dosage and duration of treatment should be adjusted based on the patient's response measured by heart rate, presence of ectopic activity, blood pressure, urine output, central venous pressure, or pulmonary wedge pressure and cardiac output. Abbreviation for infusion rate:

This medication should be used with extreme caution as glass fragments may mix when cutting the injection container, especially in children and the elderly. It should not be administered to patients with specific heart diseases or allergies to this medication. Use with caution in patients with hypertension or severe heart disease, as heart rate or blood pressure may increase. This medication can cause allergic reactions, and patients with asthma should be particularly cautious. During administration, continuous monitoring of blood pressure, heart rate, electrocardiogram, etc., is necessary to closely observe the patient's condition. Patients with insufficient blood volume should have their volume restored before administration of this medication. There may be interactions when used with other medications, so it is essential to consult medical professionals. Women who are pregnant or breastfeeding should carefully weigh benefits and risks before using this medication and should ideally discontinue breastfeeding if possible. Safety in children has not been established, and use is not recommended. In the elderly, bodily functions may be diminished, so start with a low dose and administer while closely monitoring their condition. This medication should only be administered as an intravenous drip, and care must be taken to avoid extravasation as it may cause damage to the injection site. Do not mix with specific solutions during dilution, and use within 24 hours after preparation. Overdosage may cause abnormalities in blood pressure or heart rate; thus, if symptoms arise, administration should be stopped or reduced to stabilize the patient.

Serious side effects

Shortness of breath (respiratory problem)

Mild side effects

• Rash
• fever
• eosinophilia
• bronchospasm
• tachycardia
• ectopic beats
• excessive blood pressure increase
• angina pectoris
• precordial warmth
• chest discomfort

Store this medication in a sealed container to prevent air exposure, and it is advisable to store it at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication.

Appearance

A transparent liquid that is colorless to light yellow contained in a colorless transparent ampoule injection.

Package unit

5mL/ampoule × 10