Dongkwang Lincomycin Hydrochloride Injection

Adult dosage

(Capsules) ○ Adults: For severe infections, administer 500 mg (potency) of lincomycin orally per dose every 8 hours; for very severe infections, administer 500 mg (potency) per dose every 6 hours. For beta-hemolytic streptococcal infections, continued administration for at least 10 days is recommended to prevent rheumatic fever or glomerulonephritis that may occur after treatment. Adjust the dose as appropriate according to age and symptoms. (Injection) 1. Intramuscular injection ○ Adults: For severe infections, inject 300 mg (potency) of lincomycin per dose intramuscularly 2 times daily; for very severe infections, inject 600 mg (potency) per dose intramuscularly 2 times daily. 2. Intravenous injection ○ Adults: For severe infections, administer 600 ∼ 1,000 mg (potency) of this drug per day by intravenous drip in 2 ∼ 3 divided doses; the dose may be increased for very severe infections. Adjust the dose as appropriate according to age and symptoms. 3. Method of administration This drug must be diluted before intravenous administration. Normal saline injection or 5 % dextrose injection may be used as the diluent. The dilution ratios and infusion rates are as follows. Dose (mg) Diluent volume (mL) Infusion time (hr) 600 100 1 1000 100 1 2000 200 2 3000 300 3 4000 400 4

Children's dosage

○ Children (28 days and older): For severe infections, administer 30 mg (potency) of this drug per kg of body weight per day in 3 ∼ 4 divided doses. ○ Children (28 days and older): For very severe infections, administer 60 mg (potency) per kg of body weight in 3 ∼ 4 divided doses. ○ Children (28 days and older): For severe infections, inject 10 mg (potency) of this drug per kg of body weight per day intramuscularly in 1 ∼ 2 divided doses. ○ Children (28 days and older): For severe infections, administer 10 ∼ 20 mg (potency) of this drug per kg of body weight per day by intravenous drip in 2 ∼ 3 divided doses.

This drug is used for severe infections and may occasionally cause severe colitis, which can be fatal. If colitis occurs, severe diarrhea, abdominal pain, and fever may appear, and if symptoms are severe, the drug should be discontinued or a physician should be consulted. This drug is not used for mild bacterial infections or non-bacterial upper respiratory infections. It does not penetrate well into the cerebrospinal fluid and is not suitable for treating meningitis. This drug should not be used in patients with allergies to this drug or its components, severe colitis, bacterial meningitis, and in nursing women. Caution is required for elderly patients or those with liver or kidney dysfunction, asthma, or a history of allergies, as symptoms may worsen in certain diseases. Rare side effects may include shock, severe allergic reactions, gastrointestinal disorders, interstitial pneumonia, blood disorders, skin rashes, and liver or kidney dysfunction, so any unusual symptoms should be reported to a doctor immediately. With prolonged use, regular blood and liver and kidney function tests should be conducted, and it is advisable to avoid using antidiarrheal agents for diarrhea treatment. When used with other drugs, there may be neuromuscular paralysis or drug interactions, so patients should inform their physician about any medications being taken. It is preferable that this drug not be used during pregnancy or in those who may become pregnant, and in infants or premature infants. During lactation, the drug may pass into breast milk, so breastfeeding should be discontinued. In cases of overdose, symptoms such as vomiting and diarrhea may occur, and immediate medical attention should be sought. This drug may affect blood test results, so patients should inform their doctor that they are taking this drug during tests, and surgical intervention may be required at the infection site during antibiotic administration. When used as an injectable, pain or induration may occur at the injection site, and care should be taken as rapid intravenous administration is dangerous. After use, store away from children and avoid transferring the medication to another container.

shock

This drug should be stored in a sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

A transparent ampule containing a colorless and clear solution

Package unit

50 ampules/box[(2mL/ampule)x50]