Oxychlorine Tablet 100 mg (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Adults - The initial dose is 200～400mg daily. If 400mg is administered, divide the dose. Once an effect is observed, reduce the dose to 200mg daily; if the effect is inadequate, increase the dose to 400mg daily. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. * It may take several weeks for this drug to become effective, whereas adverse effects may occur sooner. * Discontinue treatment for rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus if symptoms do not improve after 6 months of treatment. * For photosensitive diseases, administer only when there is substantial exposure. 2. Malaria 1) Treatment Adults - For treatment of acute disease, initially administer 800mg, followed by 3 additional doses of 400mg at 6∼8-hour intervals, for a total of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or Plasmodium vivax, a single dose of 800mg may also be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg weekly), starting 2 weeks before exposure.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. 2. Malaria 1) Treatment Children - Initially administer 10mg/kg of chloroquine, followed by 3 additional doses of 5mg/kg at 6-8-hour intervals, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. For children weighing 30∼40kg or less, even 1 tablet (200mg) exceeds the appropriate dose; therefore, administration is not recommended.

This medication should not be used in certain patients. For example, patients who have allergic reactions to this drug or similar compounds, patients with maculopathy or those taking medications that can cause visual impairment, pregnant or nursing women, and patients with genetic issues such as lactose intolerance may be at risk when taking this medication. Additionally, patients allergic to quinine or those with liver, kidney, heart, blood, or nervous system issues should be cautious when using this drug. Patients with skin conditions or certain blood disorders, as well as porphyria, also require caution. This medication can cause various abnormal reactions in the eyes, potentially leading to blurred vision or retinal issues. If such symptoms occur, one must immediately stop taking the medication, as severe symptoms may lead to difficult recovery. Skin reactions such as rash, hair loss, and pigmentation changes may occur, and serious skin reactions can very rarely happen, so if any abnormal symptoms appear, one should consult medical personnel immediately. Gastrointestinal discomforts such as nausea, diarrhea, and abdominal pain may arise, and symptoms like fatigue, headache, hallucinations, and muscle weakness can occur in the central and peripheral nervous systems. Due to potential effects on the heart, arrhythmias, or cardiomyopathy may occur, so patients with heart disease should pay particular attention. Regular ophthalmic examinations must be performed during the course of this medication, and if any changes in vision occur, administration should be immediately ceased, and the condition should be monitored. Patients with poor liver or kidney function should have their blood concentration monitored and dosage adjusted, and regular blood tests should also be conducted to check for bone marrow suppression. This medication may interact with other drugs, so if other medications are being taken, it is essential to inform medical personnel, and it is particularly safer not to combine with drugs that may cause heart arrhythmias. Pregnant or nursing women should not take this medication and are advised to discontinue nursing during treatment. In case of overdose, severe side effects may occur, so strict adherence to the prescribed dosage is necessary, and if overdose is suspected, immediate emergency treatment should be sought. Finally, this medication should be kept out of the reach of children and should not be transferred to other containers for safety.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacity, retinopathy, visual impairment, scotoma, color rings, glare, skin rash, urticaria, changes in pigmentation of skin and mucous membranes, hair discoloration, alopecia, vesicular rash, erythema multiforme, mucocutaneous syndrome, photosensitivity reactions, exfoliative dermatitis, Sweet's syndrome, severe cutaneous adverse reactions, acute generalized exanthematous pustulosis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, myasthenia, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neurogenic reactions, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, seizures, skeletal muscle myopathy, neuromuscular disease, perceptual changes, decreased tendon reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, bilateral ventricular hypertrophy, conduction disorders, abnormal liver function test results, fulminant hepatic failure, hepatocellular injury, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant liver failure, depression, hallucinations, anxiety, agitation, confusion, delusions, mania, sleep disturbances, weight loss, lethargy

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is best to store it at room temperature between 1 to 30 degrees Celsius. This way, the effectiveness of the medication can be maintained for a longer time.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle, 500 tablets/bottle