Pervol Injection 15 Milligrams (Polinonate Calcium)

Adult dosage

1. Standard treatment with methotrexate: Administer 6-12 mg intramuscularly every 6 hours, 4 times a day. 2. Rescue therapy with methotrexate and polinonate: Administer 15 mg via intravenous injection every 3 hours for 9 times, then, every 6 hours administer for 8 times either intravenously or intramuscularly. 3. Combined administration with 5-Fluorouracil (5-FU) for progressive colon cancer: 200 mg/m² of polinonate calcium once daily administered slowly intravenously for at least 3 minutes.

This medication is not suitable for the treatment of pernicious anemia or megaloblastic anemia due to Vitamin B12 deficiency. While neurological symptoms may continue to progress, improvement in blood conditions may also occur, warranting caution. Care must be taken when opening the ampule as glass fragments may enter, particularly when administering to children or the elderly. Pregnant or breastfeeding women should not use this medication in combination with 5-FU, and should use it cautiously if administered alone. Severe allergic reactions such as hives or anaphylaxis may occur due to hypersensitivity; notify medical personnel immediately if unusual symptoms arise. Pain or temporary discomfort may occur at the injection site, and rare instances of fever or central nervous system symptoms may also present. When combined with other anticancer agents, side effects such as diarrhea, skin problems, and stomatitis may arise, necessitating dosage adjustment if symptoms are severe. This medication should be used under the guidance of a specialist, especially during methotrexate treatment, monitoring blood concentration to determine appropriate dosage and treatment duration. Caution is required as drug excretion may be delayed in cases of renal function impairment or fluid retention in the body. There are interactions between this medication and certain anticonvulsants that may increase the risk of seizures, thus dosage should be adjusted while monitoring blood concentrations. Elderly or physically weak patients may have a higher risk of gastrointestinal side effects, requiring special attention. This medication is contraindicated for intrathecal administration, and when administered intravenously, the injection speed should be controlled due to calcium content. Store out of reach of children and keep in the original container to maintain safety and efficacy.

Serious side effects

Hives, anaphylactic reactions

Mild side effects

Vascular pain, transient pain, fever, agitation, depression, diarrhea, skin reactions, dry skin, stomatitis, conjunctivitis, mucositis, mild hematotoxicity, leukopenia, central nervous system disturbances (including paralysis disorders)

This medication may be sensitive to light, so it should be stored in an airtight container that blocks light. It is recommended to maintain the storage temperature at room temperature, avoiding excessive heat or cold.

Appearance

A colorless to light yellow transparent injection solution in a brown ampoule

Package unit

1mL - 50 ampoules/box