Medication info
Hanin Hydrochloride Clomipramine Capsule 25 Milligrams

Hanin Hydrochloride Clomipramine Capsule 25 Milligrams

Prescription medicationHard capsule
Ingredient · strength
Clomipramine Hydrochloride›25mg / 1 capsule
Manufacturer / importer
환인제약(주)
Appearance
A hard capsule with a blue top and a white bottom containing a yellowish to white powder
Packaging
500 capsules per bottle
Approval status
Active

MFDS item code 198900993 · Notified 1989.03.16 · Insurance code 657201060

Summary

Main use
Improvement of depression (endogenous, reactive, etc.), obsessive-compulsive disorder, and phobic states
Who uses it
Adults
Adult dosage
Oral: Start with 10mg daily taken orally. Gradually increase to 30-150mg daily, either divided doses or taken once at bedtime. The maintenance dose is 30-50mg daily. Intramuscular injection: Start with 25-50mg daily as an intramuscular injection. Increase the dosage by 25mg daily until receiving 100-150mg daily. When symptoms improve, gradually reduce the frequency of injections.

Ingredients

Manufacturer
환인제약(주)

Efficacy & effects

Improvement of depression (endogenous, reactive, etc.), obsessive-compulsive disorder, and phobic states

  • Depression
  • obsessive-compulsive state
  • phobic state
  • sleep attacks
  • endogenous depression
  • reactive depression
  • neurotic depression
  • organic depression
  • facsimile depression
  • degenerative depression
  • depression due to schizophrenia and personality disorders
  • depressive symptoms in old age
View approved original text

This medication is used for the treatment of various types of depression. Oral formulations are effective for depression requiring sedation, obsessive-compulsive states, phobic states, and sudden symptoms associated with sleep attacks. The injectable form improves a range of depressive states, from endogenous depression to reactive, neurotic, and organic depression, and is also used for treating depression due to schizophrenia or personality disorders, as well as depressive symptoms in old age and early adulthood. The medication is effective for depressive symptoms caused by chronic pain or chronic physical illnesses, as well as for mood disorders with psychotic and somatic symptoms. This medication is also used to treat various types of mental discomfort such as obsessive-compulsive disorder, phobias, and chronic pain states.

Dosage and Administration

Adult dosage

Oral: Start with 10mg daily taken orally. Gradually increase to 30-150mg daily, either divided doses or taken once at bedtime. The maintenance dose is 30-50mg daily. Intramuscular injection: Start with 25-50mg daily as an intramuscular injection. Increase the dosage by 25mg daily until receiving 100-150mg daily. When symptoms improve, gradually reduce the frequency of injections.

Precautions

This medication is an antidepressant used to treat psychiatric disorders such as depression. In children, adolescents, and young adults aged 18 to 24, the risk of suicidal impulses or behaviors may increase, so the risks and benefits must be carefully evaluated by the physician when administering to patients in this age group. During treatment, monitor for any abnormal changes in behavior, including the worsening of the illness, suicidal tendencies, aggression, and anger, and family members or caregivers should keep a close watch on the patient and consult the physician as needed. Certain patient groups, such as those allergic to this medication, those who have recently taken specific drugs (e.g., MAO inhibitors, SSRIs, SNRIs), patients with heart disease or glaucoma, should not take this medication. Additionally, patients with low blood pressure, cardiovascular disease, thyroid dysfunction, liver or kidney disease, seizure disorders, bipolar disorder, or a predisposition to psychosis should exercise particular caution when using this medication, and regular check-ups and monitoring are necessary. This medication can cause various side effects, including drowsiness, dizziness, indigestion, constipation, dry mouth, insomnia, anxiety, blood pressure changes, skin rashes, and liver function abnormalities. Particularly, if neurological symptoms or serious allergic reactions occur, promptly inform a healthcare professional. Women who are pregnant or nursing should consult a physician before taking this medication and are advised to gradually discontinue use before delivery. This medication is not recommended for use in children and adolescents due to insufficient evidence of safety and efficacy. Elderly individuals may be more sensitive to this medication, necessitating careful observation and dosage adjustments. In cases of overdose, serious cardiac and neurological symptoms may arise; therefore, it is essential to adhere strictly to the prescribed dosage as per the physician's instructions, and seek immediate medical attention in case of an overdose. This medication may interact with other drugs, so if you are taking any other medications, it is crucial to inform your physician or pharmacist, especially when used in conjunction with MAO inhibitors, anticoagulants, antipsychotics, and central nervous system depressants. While taking this drug, drowsiness or visual disturbances may occur, so it's important to avoid driving or operating hazardous machinery, and refrain from alcohol consumption. Finally, this medication should be stored out of the reach of children and should not be transferred to other containers.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor, high fever, severe rashes, blisters, peeling of skin, oral or ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), systemic lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, markedly reduced urine output, systemic reactions

Mild side effects

  • Drowsiness
  • fatigue
  • excitability
  • increased appetite
  • dizziness
  • tremors
  • headaches
  • confusion
  • numbness
  • hallucinations
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  • anxiety
  • mood swings
  • sleep disturbances
  • mania
  • hypomania
  • aggression
  • memory disturbances
  • depersonalization
  • worsening of depression
  • concentration difficulties
  • insomnia
  • nightmares
  • yawning
  • incoherent speech
  • mental confusion
  • speech disorders
  • muscle weakness
  • increased muscle tone
  • convulsions
  • ataxia
  • lethargy
  • sweating
  • dry mouth
  • sweating
  • constipation
  • visual disturbances
  • urinary disorders
  • flushing

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer time.

Appearance and packaging

Appearance

A hard capsule with a blue top and a white bottom containing a yellowish to white powder

Package unit

500 capsules per bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.