Medication info
Gromin Capsule 25 Milligrams (Clomipramine Hydrochloride)

Gromin Capsule 25 Milligrams (Clomipramine Hydrochloride)

Prescription medicationHard capsule
Ingredient · strength
Clomipramine Hydrochloride›25mg / 1 capsule
Manufacturer / importer
명인제약(주)
Appearance
Hard capsule containing white to pale yellow powder with a green (upper) and white (lower) shell.
Packaging
200 capsules/bottle
Approval status
Active

MFDS item code 198900902 · Notified 1989.02.16 · Insurance code 651900070

Summary

Main use
Treatment of depression (endogenous, reactive, etc.) and obsessive-compulsive disorder, phobias.
Who uses it
Adults
Adult dosage
Oral administration: The initial dose is 10 mg once daily, gradually increasing to 30-150 mg per day. Dosing can be divided or administered once at bedtime. The maintenance dose is 30-50 mg daily. Intramuscular injection: The initial dose is 25-50 mg administered intramuscularly, gradually increasing by 25 mg daily until a total of 100-150 mg is reached. Reduce the frequency of injections and maintain with oral dosage once symptoms improve. Intravenous infusion:

Ingredients

Manufacturer
명인제약(주)

Efficacy & effects

Treatment of depression (endogenous, reactive, etc.) and obsessive-compulsive disorder, phobias.

  • Depression
  • obsessive states
  • phobic states
  • sleep disturbances
  • endogenous depression
  • reactive depression
  • neurotic depression
  • organic depression
  • masked depression
  • degenerative depression
  • depression caused by schizophrenia
  • depression caused by personality disorders
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This medication is primarily used for the acute symptoms associated with depression, obsessive states, phobic states, and sleep disturbances requiring sedative effects. In injectable form, it is effective for various types of depression (endogenous, reactive, neurotic, organic, etc.), depression caused by schizophrenia and personality disorders, depressive symptoms in old age and early old age, and depression due to chronic pain or chronic physical illnesses. Additionally, it is used for depressive mood disorders accompanied by reactive, neurotic, psychotic symptoms as well as obsessive-compulsive disorder, phobias, and chronic pain. In summary, this medication is widely used for the improvement of various forms of depression and anxiety-related symptoms.

Dosage and Administration

Adult dosage

Oral administration: The initial dose is 10 mg once daily, gradually increasing to 30-150 mg per day. Dosing can be divided or administered once at bedtime. The maintenance dose is 30-50 mg daily. Intramuscular injection: The initial dose is 25-50 mg administered intramuscularly, gradually increasing by 25 mg daily until a total of 100-150 mg is reached. Reduce the frequency of injections and maintain with oral dosage once symptoms improve. Intravenous infusion:

Precautions

This medication is used to treat depression or other psychiatric disorders. While taking this medication, particularly in children, adolescents, and young adults, there may be an increased risk of suicidal thoughts or behaviors, and careful observation is required. It should not be used in patients who are allergic to this medication or are taking certain other medications, and in those with heart disease or glaucoma. Patients with low blood pressure, heart disease, thyroid issues, or impaired liver or kidney function need to be cautious when using this medication and should consult their healthcare provider. Possible side effects of this medication include drowsiness, dizziness, dry mouth, constipation, insomnia, anxiety, irregular heartbeat, and in severe cases, should be reported to a healthcare provider immediately. Especially during treatment, it is recommended to avoid driving or operating hazardous machinery, and taking with alcohol or other central nervous system depressants may exacerbate side effects. Women who are pregnant or breastfeeding should consult a physician before taking this medication; those breastfeeding are advised to discontinue breastfeeding or the medication. The safety and efficacy of this medication have not been established in children and adolescents, so use is not recommended. In the elderly, decreased drug metabolism may increase the risk of side effects, necessitating more cautious use. In case of overdose, serious heart issues or neurological disturbances may occur, and immediate emergency treatment is necessary. This medication must be kept out of reach of children and it is advised to avoid transferring it to another container.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe rashes with high fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or breathing difficulties, asthma attacks, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, significant decrease in urine output.

Mild side effects

  • Drowsiness
  • fatigue
  • agitation
  • increased appetite
  • dizziness
  • tremors
  • headache
  • confusion
  • localized sensory loss
  • hallucinations
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  • anxiety
  • bi-monthly disturbances
  • sleep disorders
  • hypomania
  • hypomanic episodes
  • aggression
  • memory impairment
  • derealization
  • worsening of depression
  • concentration difficulties
  • insomnia
  • nightmares
  • yawning
  • incoherence
  • mental confusion
  • speech disorders
  • muscle weakness
  • muscle rigidity
  • activation of psychotic symptoms
  • convulsions
  • ataxia
  • epileptic seizures
  • abnormal high fever
  • lethargy
  • sweating
  • thirst
  • sweating

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent air exposure, ideally at room temperature between 1 to 30 degrees Celsius. This way, the efficacy of the medication can be maintained and deterioration can be avoided.

Appearance and packaging

Appearance

Hard capsule containing white to pale yellow powder with a green (upper) and white (lower) shell.

Package unit

200 capsules/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.