Medication info
Zanapam Tablet 0.25 mg (Alprazolam)

Zanapam Tablet 0.25 mg (Alprazolam)

Prescription medicationTabletOral
Ingredient · strength
Alprazolam›0.25mg / 1 tablet
Manufacturer / importer
Myungin Pharmaceutical Co., Ltd.
Appearance
White oval tablet
Packaging
30 tablets/bottle, 200 tablets/bottle
Approval status
Active

MFDS item code 198702209 · Approved 1987.12.02 · Insurance code 651901730

Summary

Main use
Relief of symptoms of anxiety disorders, anxiety (including when accompanied by depression), panic disorder, and psychosomatic disorders
Who takes it
Adults
Adult dose
To achieve the greatest benefit, determine the dose for each individual. The usual daily doses listed below are suitable for most patients, but higher doses may be required. In such cases, increase the dose gradually to avoid adverse effects. The risk of dependence may increase with the dose and duration of treatment. Therefore, administer the lowest effective dose for the shortest possible period and frequently reassess the need to continue treatment. 1. As the initial dose, administer 0.25-0.5㎎ of alprazolam per dose 3 times daily, with a maximum dose of 4㎎ per day. For elderly patients, patients with hepatic impairment, and debilitated patients, the initial dose is 0.25㎎ per dose 2-3 times daily. Reduce the dose if adverse effects occur at the initial dose. 2. Psychosomatic disorders Administer 1.2㎎ of this medicine per day orally in 3 divided doses. If increasing the dose, increase it gradually up to a maximum of 2.4㎎ per day and administer orally in 3-4 divided doses. For elderly patients, the initial dose is 0.4㎎ per dose 1-2 times daily, with a maximum dose of 1.2㎎ per day. 3. Panic disorder Start with an initial dose of 0.5㎎ of this medicine and, depending on the patient's response to treatment, increase the dose by no more than 1㎎ at intervals of 3-4 days, to an average total daily dose of 5-6㎎ administered in 3-4 divided doses. When discontinuing treatment, reduce the dose by no more than 0.5㎎, usually at 3-day intervals; a slower reduction may be necessary in some cases.

Ingredients

Manufacturer
Myungin Pharmaceutical Co., Ltd.

Efficacy & effects

Relief of symptoms of anxiety disorders, anxiety (including when accompanied by depression), panic disorder, and psychosomatic disorders

  • Anxiety disorders
  • anxiety symptoms
  • anxiety accompanying depression
  • psychosomatic disorders
  • gastric ulcers
  • duodenal ulcers
  • irritable bowel syndrome
  • autonomic nervous system imbalance
  • anxiety
  • tension
  • depression
  • sleep disturbances
View approved original text

This medication is used to treat various symptoms associated with anxiety disorders. It provides short-term relief from anxiety symptoms and improves anxiety associated with depression. It also helps relieve anxiety, tension, depression, and sleep disturbances that occur in psychosomatic disorders such as gastric and duodenal ulcers and irritable bowel syndrome. Lastly, it effectively manages symptoms of panic disorders. Overall, this drug is used to improve various symptoms related to anxiety.

How to take

Adult dose

To achieve the greatest benefit, determine the dose for each individual. The usual daily doses listed below are suitable for most patients, but higher doses may be required. In such cases, increase the dose gradually to avoid adverse effects. The risk of dependence may increase with the dose and duration of treatment. Therefore, administer the lowest effective dose for the shortest possible period and frequently reassess the need to continue treatment. 1. As the initial dose, administer 0.25-0.5㎎ of alprazolam per dose 3 times daily, with a maximum dose of 4㎎ per day. For elderly patients, patients with hepatic impairment, and debilitated patients, the initial dose is 0.25㎎ per dose 2-3 times daily. Reduce the dose if adverse effects occur at the initial dose. 2. Psychosomatic disorders Administer 1.2㎎ of this medicine per day orally in 3 divided doses. If increasing the dose, increase it gradually up to a maximum of 2.4㎎ per day and administer orally in 3-4 divided doses. For elderly patients, the initial dose is 0.4㎎ per dose 1-2 times daily, with a maximum dose of 1.2㎎ per day. 3. Panic disorder Start with an initial dose of 0.5㎎ of this medicine and, depending on the patient's response to treatment, increase the dose by no more than 1㎎ at intervals of 3-4 days, to an average total daily dose of 5-6㎎ administered in 3-4 divided doses. When discontinuing treatment, reduce the dose by no more than 0.5㎎, usually at 3-day intervals; a slower reduction may be necessary in some cases.

Precautions

This drug can be very dangerous when used with narcotics. Taking both medications together can lead to severe drowsiness, respiratory arrest, loss of consciousness, and even death, so it should only be used in necessary cases at the minimum dose and for a short duration. This drug acts as a central nervous system depressant, and taking it with alcohol or other sedatives can enhance its effects and increase risks. Therefore, such medications or alcohol should be avoided. There is a risk of abuse or misuse of this drug, so it should be taken exactly as directed by a physician, and any remaining medications should be stored safely or discarded properly. This drug should not be used in patients with certain conditions. For example, it should not be taken by individuals allergic to this drug or similar medications, those with acute angle-closure glaucoma, severe myasthenia gravis, severe respiratory distress, severe liver dysfunction, severe psychotic depression, sleep apnea, those with alcohol or drug dependency, late-stage pregnant women, and individuals with hereditary lactose intolerance. Patients with heart, liver, or kidney issues, those with brain injuries, elderly individuals, frail patients, moderate respiratory failure patients, and those allergic to specific dyes should use this medication cautiously. Abruptly stopping this medication can lead to withdrawal symptoms such as insomnia, tremors, and seizures, so dosage should be gradually reduced under a physician's direction. Drowsiness, decreased concentration, and slowed reflexes may occur during treatment, so driving or operating hazardous machinery should be avoided. Long-term use may require regular blood tests and liver function tests. This drug may interact with several other medications, so if you are taking other medications, it is essential to inform your doctor or pharmacist, especially when taking antifungal agents, certain antidepressants, narcotic analgesics, anticonvulsants, and some antibiotics. Pregnant or breastfeeding women should consult a physician before taking this medication and should avoid it, especially during the late stages of pregnancy. For children under 18 years, the safety and efficacy of this drug have not been adequately established, so it is advisable not to use it. In case of overdose, severe drowsiness, impaired motor coordination, coma, and respiratory depression may occur; therefore, immediate contact with a medical facility is required for appropriate treatment. This drug should be kept out of reach of children and stored in its original container to prevent misuse.

Side effects

  • Mild discomfort
  • insomnia
  • abdominal and muscle cramps
  • vomiting
  • sweating
  • tremors
  • convulsions
  • seizures
  • excitement
  • increased muscle rigidity
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  • sleep disturbances
  • hallucinations
  • anxiety
  • anger
  • drug dependence
  • aggression
  • hostility
  • abnormal thoughts
  • psychomotor agitation
  • drug abuse
  • sedation
  • drowsiness
  • ataxia
  • memory impairment
  • speech disturbances
  • dizziness
  • headache
  • balance disorders
  • coordination disorders
  • attention deficits
  • hypersomnia
  • hypersomnolence
  • tremors
  • amnesia
  • autonomic nervous system imbalance
  • muscle tone abnormalities
  • blurred vision
  • constipation
  • dry mouth
  • nausea
  • gastrointestinal disturbances
  • hepatitis
  • liver function abnormalities
  • jaundice
  • dermatitis
  • angioedema
  • photosensitivity reactions
  • muscle weakness
  • urinary incontinence
  • urinary retention
  • sexual dysfunction
  • menstrual disorders
  • fatigue
  • irritability
  • drug withdrawal syndrome
  • peripheral edema
  • weight loss
  • weight gain
  • increased intraocular pressure
  • drowsiness
  • mild headache
  • depression
  • confusion
  • insomnia
  • neuroirritability
  • syncope
  • lightheadedness
  • inability to sit still
  • dry mouth
  • diarrhea
  • increased salivation
  • tachycardia
  • palpitations
  • hypotension
  • dermatitis
  • nasal congestion
  • weight gain
  • weight loss
  • fatigue
  • coordination disorders
  • memory impairment
  • involuntary movement disorders
  • decreased libido
  • confused state
  • muscle single contraction
  • increased libido
  • changes in libido
  • weakness
  • abnormal muscle tone
  • syncope
  • inability to sit still
  • anxiety
  • disinhibition
  • sensory disturbances
  • paroxysmal symptoms
  • vascular movement disorders
  • unreality
  • abnormal dreams
  • fear
  • warm feelings
  • decreased salivation
  • abdominal discomfort
  • chest pain
  • hyperventilation
  • upper respiratory tract infections
  • tinnitus
  • muscle cramps
  • muscle rigidity
  • sweating
  • rash
  • increased appetite
  • decreased appetite
  • urination disorders
  • menstrual disorders
  • erectile dysfunction
  • edema
  • urinary incontinence
  • infections
  • seizures
  • depersonalization
  • taste changes
  • double vision
  • increased bilirubin
  • elevated liver enzymes
  • jaundice
  • delirium
  • apathy
  • hyperactivity
  • dyspepsia
  • asthenia
  • chest pain
  • fatigue
  • falling
  • ataxia
  • balance disturbances
  • difficulty concentrating
  • hypersomnia
  • hypersomnolence
  • muscle weakness
  • elevated liver enzymes
  • Stevens-Johnson syndrome
  • gynecomastia
  • excessive milk secretion

Not everyone experiences these, and they can vary from person to person.

Storage

This drug is sensitive to light and should be stored in a container that blocks light. Additionally, it is important to store the medication at a temperature between 1 to 30 degrees Celsius to maintain its effectiveness.

Appearance and packaging

Appearance

White oval tablet

Package unit

30 tablets/bottle, 200 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.