Youngjin Intraphusin 10% Injection

Adult dosage

For adults, intravenously drip at a maximum dosage of 1-1.5 g of total amino acids per kg of body weight daily. The infusion rate should ideally be a concentration of about 10 g of total amino acids over 60 minutes, adhering to the principle of administering 30-40 drops per minute.

Children's dosage

For children, the dosage and infusion rate should be appropriately adjusted.

This medication must be used according to a doctor's instructions. It should not be used in patients with hepatic coma or at risk of hepatic coma, severe renal impairment, hypernitrogenemia, metabolic disorders with nitrogen utilization issues, heart failure, or pulmonary edema. Do not administer to patients with low or absent urinary output, acidosis, excess body fluid, hypokalemia, or those in shock. It should be used with caution in patients with congestive heart failure or impaired liver and kidney function, as side effects such as skin rash, nausea, vomiting, chest discomfort, palpitations, and increased blood pressure may occur. Rapid large doses can cause acidosis, and rarely symptoms such as chills, fever, headache, dyspnea, and shock may occur. Metabolic complications may include acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin imbalance, electrolyte abnormalities, and childhood hyperammonemia. Patients with impaired liver or kidney function may have elevated levels of blood urea nitrogen (BUN), and patients with liver failure may demonstrate severe symptoms such as serum amino acid imbalance or coma. Beware of electrolyte balance when administering large doses or using it with electrolyte solutions, as excessive administration can lead to metabolic alkalosis. In patients with a history of kidney disease, lung disease, or heart disease, it must be administered carefully while avoiding excessive fluid supply. Diabetic patients should frequently monitor their blood glucose levels. This medication may reduce the protein-sparing effect when used with specific antibiotics such as tetracycline. The safety for pregnant women has not been established, and it should only be used when the benefit outweighs the risk. In children, due to immature liver function, hyperammonemia can occur, so the concentration should be kept low and blood ammonia levels should be monitored frequently. In the elderly, given the decreased physical function, the administration rate should be slow and the dosage adjusted. This medication should be administered slowly intravenously, as rapid injection can cause chills or vomiting. Before use, adjust the temperature to body temperature, and ensure aseptic conditions for preparation and management. Do not use if the solution is cloudy or discolored, and it should be stored in the refrigerator for no more than 24 hours. If crystals form, dissolve by heating and cool to body temperature before use. Care must be taken to prevent discoloration until the packaging is opened, and it should not be used if the container or stopper is damaged. It is safer for patients with a history of myocardial infarction not to use this medication.

Serious side effects

• Hives
• severe swelling (edema)
• chest tightness
• dyspnea
• cold sweat
• pallor
• rash with high fever
• skin peeling
• pain in oral/ocular mucosa
• respiratory distress

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• tachycardia
• increased blood pressure
• chills
• fever
• headache

This medication should be stored in a sealed container to prevent air and moisture ingress, preferably at room temperature. This will help maintain the drug's efficacy and prevent degradation.

Appearance

A colorless-yellowish solution in a colorless transparent glass bottle sealed with a rubber stopper for infusion.

Package unit

250 mL/bottle, 500 mL/bottle