DaeWon Sodium Bicarbonate Injection (8.4%)

Adult administration

As sodium bicarbonate, 1–5g (12–60mEq) should be administered by intravenous injection. For acidosis, the usual dose is calculated according to the following formula and administered intravenously. Required dose (mEq) = Base Deficit (mEq/L) × 0.2 × Weight (kg) Adjust appropriately according to age and symptoms.

When using this drug as an injection, the glass ampule must be broken carefully. If glass fragments mix in, it can cause harmful reactions in the body. Extra caution should be taken when administering to children or the elderly. This drug should not be used in individuals with certain conditions such as kidney disease, alkalosis, hypertension, edema, or weakened heart function. In these cases, the drug may worsen the condition. In patients who are pregnant or in special situations such as newborns or those with heart failure, this drug should be administered cautiously due to a higher risk of side effects. Excessive administration of this drug can lead to various serious side effects such as electrolyte imbalance, muscle spasms, respiratory distress, and cardiac arrhythmias. If these symptoms occur, administration should be stopped immediately, and appropriate treatment should be received. Inflammation or tissue damage may occur at the site of administration, so care must be taken to inject it precisely into the vein. Additionally, there may be rare side effects such as neurological abnormalities, fever, and nausea. When administering this drug, blood acidity and carbon dioxide levels should be monitored regularly to prevent alkalosis. Also, sufficient ventilation is essential during cardiopulmonary resuscitation. Interactions with other medications may occur, so patients on steroids, diuretics, potassium supplements, etc. should inform their doctor or pharmacist and use with caution. Pregnant or breastfeeding women should only use this drug when necessary, and it is advised to discontinue breastfeeding during treatment as the safety of this medication has not been established. When administered to newborns, if given at a high concentration, there is a risk of brain hemorrhage, so it should be diluted and administered slowly. Elderly patients require slower administration rates and dosage adjustments due to diminished physical function. In the case of overdose, treatment to control acidity and replenish electrolytes should be initiated immediately. This drug should not be mixed with other medications, and it must not be used with calcium-containing drugs to prevent precipitation. Before administration, check that the solution is clear, and once opened, use it immediately; any remaining medication should be discarded. During injection, care must be taken to inject it accurately into the vein and to prevent leakage outside the vein. This drug should be kept out of reach of children and stored in its original container to prevent degradation or misuse.

Serious side effects

• Convulsions
• rigidity
• compensatory hyperventilation
• pulmonary edema
• tissue inflammation
• necrosis and ulcers
• brain dysfunction
• insensitivity
• seizures
• peripheral tissue hypoxia

Mild side effects

• Prolonged blood coagulation time
• excessive excitement
• dry mouth
• thirst
• arrhythmia
• emotional or mental changes
• lip numbness
• altered perception
• vascular pain
• fever

This drug should be stored in a sealed container to avoid contact with air, and it is best to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the drug's efficacy over time.

Appearance

A colorless, transparent liquid in a colorless, transparent plastic ampule.

Package unit

20mL/ampule (PE) X 50