Urantak 100 mg (Ranitidine Hydrochloride)

Adult dosage

As ranitidine, inject 50 mg intravenously or intramuscularly 3-4 times daily. For intravenous injection, dilute this medication 50 mg in 20 mL of normal saline or dextrose solution and administer slowly for at least 2 minutes or mix in intravenous fluids and administer as a drip infusion at a rate of 25 mg/hr over 2 hours. In cases of upper gastrointestinal bleeding, if effectiveness is seen within a week, it can be switched to oral administration when possible.

Children's dosage

Clinical studies in children have not been established.

This medicine should not be used in patients with a history of allergic reactions to this medication or its components. Caution is required for patients with impaired kidney function as this medication may not be properly excreted, leading to increased blood concentration, thus dosage reduction or extended dosing intervals may be necessary. Patients with impaired liver function must also be particularly cautious when using this medication. Patients who have previously experienced drug allergic reactions or older adults should be administered this medicine carefully. Additionally, it is advisable to avoid this medication in patients with a history of the rare condition acute porphyria. When using this medication, careful observation of the patient's condition is necessary due to the potential for allergic reactions or serious side effects. If symptoms such as hives, rashes, difficulty breathing, or low blood pressure occur, discontinue use immediately and seek appropriate treatment. Blood-related side effects can rarely include leukopenia, thrombocytopenia, and anemia; therefore, tests should be conducted if symptoms such as fatigue, bleeding, or fever occur. If symptoms of liver dysfunction or jaundice arise, the use of this medication should be discontinued immediately. Heart-related side effects may rarely include bradycardia or arrhythmias, so patients with heart conditions should be particularly cautious. Gastrointestinal symptoms can rarely include constipation, nausea, vomiting, and abdominal pain. Neurological side effects may include dizziness, drowsiness, headache, insomnia, confusion, and hallucinations occasionally reported, especially in older adults or those with impaired kidney function. Myalgia or arthralgia may occur and, rarely, serious muscle damage such as rhabdomyolysis may occur, so consult a physician immediately if any problems arise. Skin changes such as rashes, alopecia, or itching may occur, so notify someone if any skin changes happen. This medication requires regular monitoring of liver function, kidney function, and blood test values while closely observing therapeutic effect and side effects. Older adults, patients with chronic lung disease, diabetes, and those with weakened immune systems may be at higher risk for pneumonia and need to be monitored closely. This medication can interact with other drugs, so be sure to inform about any medications currently being taken, especially when taking anticoagulants, frequent checks of coagulation status are necessary. Women who are pregnant or may become pregnant and those who are breastfeeding should consult a physician before using this medication, considering the potential effects on the fetus or infant. Safety in children has not been sufficiently established, so caution should be exercised when used in pediatric patients. In case of overdose, appropriate emergency measures such as vomiting or gastric lavage should be taken, and if necessary, dialysis may be performed to remove the medication. When administered via injection, pain or induration at the injection site may occur, and in patients concerned about abnormal heart rates, it should be infused slowly. This medication may mask symptoms of gastric cancer, so patients with gastric ulcers or new or changed digestive symptoms in middle-aged and older patients should confirm malignancy before use. Long-term use may affect ocular tissues, so eye examinations should be conducted cautiously.

Serious side effects

• Hives
• angioedema
• anaphylactic shock
• severe allergic reactions
• generally reversible jaundice
• hepatitis
• cardiac arrest
• seizures
• altered consciousness
• myoclonic jerks

Mild side effects

Rash, fever, hypotension, chest pain, angioedema, granulocytopenia, increased serum creatinine levels, leukopenia, thrombocytopenia, liver function impairment (increased levels of AST, ALT, γ-GTP, ALP), bradycardia, AV block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distention, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, heaviness in the head, insomnia, excitement, anxiety, mental confusion, depression, hallucinations, blurred vision.

This medicine should be stored in a closed container that blocks light and should preferably be kept at room temperature. Therefore, it should be protected from direct sunlight and stored at a safe temperature away from extreme heat or cold.

Appearance

A colorless to yellowish transparent solution or a brown ampoule form.

Package unit

1 ampoule (4 mL) × 50