Ranitakjeong (Ranitidine Hydrochloride)

Adult dose

As ranitidine, a single dose of 150 mg is administered orally twice daily in the morning and at bedtime. - Gastric and duodenal ulcers: administer 150 mg twice daily or 300 mg once daily at bedtime; for duodenal ulcers, 300 mg may be administered twice daily. - Gastroesophageal reflux disease: administer 150 mg twice daily or 300 mg once daily at bedtime for 8 weeks; for severe cases, may administer 150 mg four times daily.

Child dose

For children aged 8 to 18 years, a single dose of 150 mg (2 mg per kg of body weight) may be administered twice daily.

This medication should not be used in patients who have had hypersensitivity reactions to any component of this medication. Patients with a history of acute porphyria should be cautious as this medication may induce seizures. Since it contains lactose, patients with genetic issues such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take it. Patients with impaired renal function may require dose adjustments due to increased blood concentration since this medication is excreted through the kidney. Caution is also needed in patients with reduced liver function, those with a history of drug hypersensitivity, and the elderly. Patients taking NSAIDs, particularly the elderly or those with a history of peptic ulcers, require regular monitoring. This medication may mask symptoms of gastric cancer; therefore, gastric ulcer patients or those with newly arising or changing dyspeptic symptoms in middle-aged or older patients should confirm the nature of the illness before use. Patients with Helicobacter pylori infection and gastric or duodenal ulcers require eradication therapy. This medication may occasionally cause hypersensitivity reactions such as anaphylactic shock, urticaria, angioedema, rash, fever, or bronchospasm; therefore, administration should be stopped immediately if any abnormal symptoms occur. Various adverse effects have been reported, including blood abnormalities, liver dysfunction, cardiac rhythm disorders, gastrointestinal symptoms, neuropsychiatric symptoms, musculoskeletal pain, and skin rashes; prompt action is necessary upon symptom occurrence. When treating, the patient's condition should be closely monitored, and the minimum necessary dose should be administered. If there is no effect, alternative treatment methods should be considered. There may be an increased risk of pneumonia in the elderly, patients with chronic pulmonary disease, those with diabetes, and immunocompromised patients. Patients experiencing dizziness or drowsiness should avoid driving or operating dangerous machinery. This medication may interact with other drugs, so it is essential to inform the healthcare provider of any other medications being taken, especially while taking anticoagulants; blood tests to monitor the condition should be performed closely. The use of this medication in pregnant women or those who may become pregnant should be carefully considered, and during breastfeeding, it should only be used if the benefits outweigh the risks. The safety in children has not been adequately confirmed, so caution is required. The elderly may experience an increased blood concentration due to decreased kidney function, so dose and administration intervals should be adjusted. There are no specific major problems reported in cases of overdose; however, appropriate treatment such as vomiting or gastric lavage may be necessary, and blood dialysis may be considered if needed. This medication should be kept out of the reach of children and transferring it to another container is not advisable for quality maintenance. Long-term administration may require ophthalmologic examinations due to its affinity for ocular melanin. Caution is also needed as the use of this medication may promote bacterial overgrowth in the stomach due to reduced stomach acid secretion.

Serious side effects

Urticaria, angioedema (severe swelling), anaphylactic shock (severe allergic reaction), bronchospasm, chest pain, angioedema, acute pancreatitis, hepatitis (possibly with jaundice), acute interstitial nephritis, seizures, altered consciousness, tonic-clonic seizures, aplastic anemia, agranulocytosis, thrombocytopenic purpura, acquired autoimmune hemolytic anemia, bone marrow suppression, thrombocytopenia, leukopenia, Stevens-Johnson syndrome, toxic epidermal necrolysis,

Mild side effects

Rash, fever, angioedema, hypotension, chest pain, granulocytopenia, increased serum creatinine level, leukopenia, thrombocytopenia, reversible liver dysfunction (increased AST, ALT, γ-GTP, ALP), bradycardia, atrioventricular block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, feeling of heaviness in the head, insomnia, agitation, anxiety, mental confusion, depression, hallucinations, blurred vision,

This medication is sensitive to light and should be stored in a tightly sealed container that blocks light. Additionally, to maintain the drug's effect, it is best to store it at room temperature, specifically between 1 and 30 degrees Celsius.

Appearance

Round film-coated tablet, pale to light yellow

Package unit

30 tablets/bottle, 100 tablets/bottle