Myeongmun Inopan Injection (Dopamine Hydrochloride)

Adult administration

As dopamine hydrochloride, it is administered intravenously at a dose of 2-5 µg/kg/min. In severe cases, the dose may be increased to 5-10 µg/kg/min up to 20-50 µg/kg/min. Adjust according to age and symptoms.

This medication may contain glass particles when opening the ampoule, so extra caution should be taken, especially when used in children or the elderly. This medication should not be used in patients with certain conditions. For example, it should not be administered to patients with pheochromocytoma, tachyarrhythmias, ventricular fibrillation, hyperthyroidism, or closed-angle glaucoma. Patients with peripheral vascular disorders or who are allergic to sulfites should use this medication cautiously. Asthma patients sensitive to sulfites require special attention. This drug can cause cardiovascular side effects such as cardiac arrhythmias, ischemia due to peripheral vascular constriction, tachycardia, angina pectoris, and palpitations, thus the patient's condition should be closely monitored during administration. Additionally, gastrointestinal side effects such as nausea, vomiting, abdominal pain, and neurological effects such as headache, anxiety, and inflammation at the injection site may also occur. Depending on the shock state, fluid, blood transfusion, and respiratory management may be necessary; if there is a deficiency in blood volume, it should be supplemented first. If the pulse decreases during administration, the dosage should be reduced and the patient should be monitored closely. This drug may interact with certain anesthetics, MAO inhibitors, and antidepressants, so caution is required when co-administered, and dosage adjustments may be necessary. Women who are pregnant or may become pregnant should only use this medication when the benefits of treatment outweigh the risks, and lactating women should avoid administration if possible or discontinue breastfeeding. Safety and efficacy in children have not been established, so it is advisable not to use in pediatric patients. In elderly patients, due to decreased bodily functions, the risk of side effects is greater, so starting with a low dose and monitoring the condition is recommended. To prevent tissue damage at the injection site, it is advisable to administer the injection into a large vein, particularly the antecubital vein, and appropriate measures should be taken in case of tissue infiltration. This medication's efficacy may be reduced when used with alkaline solutions, so it should not be diluted with alkaline solutions like 5% sodium bicarbonate and should be used within 24 hours after dilution.

Serious side effects

• Dyspnea
• Severe edema accompanied by elevated blood pressure
• Risk of severe allergic reactions (sulfite anaphylaxis, asthma attacks)

Mild side effects

• Possible arrhythmias such as ventricular extrasystole, atrial fibrillation, ventricular tachycardia
• Risk of ischemia due to peripheral vascular constriction
• Tachycardia, angina pectoris, palpitations, hypotension, abnormal conduction, bradycardia, increased QRS duration, hypernitrogenemia, elevated blood pressure
• Nausea, vomiting, abdominal distention, abdominal pain, paralytic ileus
• Headache, anxiety, phlebitis, necrosis at the injection site, oral symptoms

This medication may be sensitive to light and should be stored in a light-protected container. It is also important to store it at room temperature, that is, in a typical indoor temperature that is not too hot or cold, to maintain the drug's efficacy.

Appearance

A brown transparent ampoule containing a colorless to pale yellow transparent liquid

Package unit

1 ampoule (5mL)*50 (For export) 1 ampoule (5mL)*10,50