Trizel Injection (Metronidazole)

Adult dosage

Tablets: For the treatment of trichomoniasis, administer 250 mg orally twice a day for 10 days. For the treatment of anaerobic infections, administer 500 mg orally 3 to 4 times a day, with a maximum daily dose not exceeding 4 g. The treatment duration is usually between 7 to 10 days. For postoperative prevention, the initial dose is 1 g, followed by 250 mg orally three times a day. For amoebiasis treatment, 500-750 mg orally

Children's dosage

Injection: For the treatment of anaerobic infections, children aged 12 and older should receive 500 mg (100 mL) intravenously every 8 hours, similar to adults. Children under 12 years old should receive 1 intravenous dose of this medication at a rate of per body weight kg.

This medication has been reported to cause tumor formation in rodent studies, so unnecessary use should be avoided. In patients with cocaine syndrome, administration of this medication may lead to serious hepatotoxicity or acute liver failure; therefore, liver function tests must be conducted, and hepatic function should be periodically monitored during and after treatment. If liver function deteriorates sharply, administration of this medication should be stopped immediately, and any signs of liver damage should be reported to a doctor without delay. This medication should not be used in patients who have an allergy to this drug or its components, have a history of blood disorders or neurological diseases, in pregnant women during the first three months of pregnancy, and in patients taking certain medications. Alcohol-dependent patients taking disulfiram should not be administered this medication, as it may cause psychotic reactions; alcohol consumption should be avoided during and for three days after treatment. Care should be taken when using this medication in patients with liver dysfunction, pregnant women beyond three months, patients with central nervous system infections, and patients requiring sodium restriction. This medication may cause various side effects in the gastrointestinal tract, blood, skin, and nervous system, so any unusual symptoms should be communicated to healthcare professionals immediately. In particular, if serious adverse reactions occur on the skin, administration should be stopped immediately, and care should be taken to avoid driving or operating machinery if confusion, hallucinations, convulsions, or visual disturbances occur. This medication may interact with anticoagulants such as warfarin, increasing the risk of bleeding; therefore, blood tests are necessary to adjust the dosage during treatment. Care should be taken when used in conjunction with drugs like lithium, phenytoin, phenobarbital, 5-FU, and cyclosporine due to the risk of changes in drug concentration or side effects. During pregnancy, this medication may affect the fetus, so it should not be administered to pregnant women within three months; breastfeeding should be discontinued as this drug's components can pass into breast milk. In case of overdose, there is no specific antidote, so general treatment should be administered, and it should not be mixed with other antibiotics for injection or administered via routes other than intravenous drip. Any leftover medication should not be used, and this medication should be managed as a stock solution that requires no compounding.

Serious side effects

Urticaria, severe swelling (edema), anaphylactic shock, severe hepatotoxicity/acute liver failure, jaundice, hepatitis, skin and mucous membrane syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, drug reaction (DRESS), acute generalized exanthematous pustulosis (AGEP), severe skin adverse reactions, convulsive seizures, encephalopathy, subacute cerebellar syndrome, severe neurological symptoms, blood disorders (moderate leukopenia, neutropenia

Mild side effects

• Nausea
• vomiting
• diarrhea
• oral mucositis
• taste disturbance
• loss of appetite
• epigastric pain
• fatigue
• drowsiness
• headache

This medication should be stored in a sealed container to avoid exposure to air. It is recommended to store it in a cool place, away from direct sunlight, at room temperature between 1 and 30 degrees Celsius. Additionally, it should be kept in a safe place inaccessible to children or animals.

Appearance

A colorless to pale yellow transparent liquid contained in a colorless transparent glass vial or polypropylene container

Package unit

100 milliliters