Monocin Tablet (Doxycycline Hyclate Hydrate)

Adult dose

○ Adults: The initial dose is 100 mg (potency) of doxycycline orally every 12 hours. The maintenance dose is 100 mg (potency) per day in 1 ∼ 2 divided doses. ○ For severe infections, administer the initial dose every 12 hours. This drug should be administered for an additional 24 ～ 48 hours after symptoms have subsided and the fever has resolved. For streptococcal infections, continue administration for at least 10 days to prevent the development of rheumatic fever or glomerulonephritis. Dosage may be adjusted according to age and symptoms.

Child dose

○ Adolescents aged 12 years and older: For those weighing 45 kg or less, the initial dose is 4 mg (potency) per kg of body weight per day, administered orally in 2 divided doses. The maintenance dose is 2 mg (potency) per kg of body weight per day in 1 ∼ 2 divided doses. ○ Adolescents aged 12 years and older: For those weighing more than 45 kg, administer the dose corresponding to the adult dosage.

This medication may cause diarrhea and colitis due to Clostridium difficile, so if diarrhea symptoms appear after ingestion, it is essential to inform the medical personnel immediately. Severe skin reactions can occur; if a rash, red spots, or blisters appear on the skin, stop taking the medication immediately and visit a hospital. Individuals allergic to this medication or tetracycline-class drugs should not use it. It is advisable for pregnant or nursing women, as well as children under 12 years old, to avoid taking this medication. Patients with severely impaired kidney or liver function should use this medication cautiously, and dosage adjustments and regular monitoring may be necessary. Exposure to direct sunlight or UV radiation can make the skin prone to sunburn, so it is recommended to apply sunscreen and protect the skin when going outside. This medication can irritate the esophagus; therefore, take it while sitting or standing with sufficient water, and do not take it just before bedtime. As there may be interactions with other medications, it is crucial to inform healthcare providers of any other drugs being taken, particularly when used in conjunction with oral contraceptives, antacids, and anticoagulants. During long-term use, regular checks for liver, kidney, and blood conditions should be conducted to monitor for abnormalities. Elderly individuals may have reduced bodily function and a higher risk of side effects; thus, starting with a lower dose while closely observing their condition is essential. Taking this medication during pregnancy could affect the skeletal development of the fetus; therefore, it is safer for women who might become pregnant to avoid it. There may be a risk of bleeding due to vitamin K deficiency while taking this medication, so caution is advised. In case of overdose, symptoms such as vomiting, liver and kidney damage, and esophagitis may occur, and immediate medical treatment is required. This medication should be kept out of reach of children and stored in its original container.

Diarrhea, colitis, exfoliative dermatitis, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, hemolytic anemia, neutropenia, thrombocytopenia, hypersensitivity, anaphylactic shock, angioedema, exacerbation of systemic lupus erythematosus, pericarditis, serum sickness, hypotension, dyspnea, tachycardia, peripheral edema, urticaria, thyroid microscopic dark brown discoloration, decreased appetite, headache, benign intracranial hypertension, protuberance of the optic disc, tinnitus, flushing, nausea, vomiting, dyspepsia, pancreatitis, pseudomembranous colitis, esophageal ulcer, esophagitis, enterocolitis, perianal genital inflammatory lesions, dysphagia, abdominal pain, glossitis, discoloration of teeth, hepatotoxicity, hepatitis, abnormal liver function, photosensitivity response, rash, exfoliative dermatitis, photo-onycholysis, arthralgia, myalgia, increased BUN, anemia, decreased granulocytes, atypical lymphocytes, decreased lymphocytes, lymphadenopathy, coagulation disorders, anaphylactic reaction, fever, sensory disturbances, anxiety, agitation, severe colitis with melena, loose stools, stomatitis, pharyngitis, black hairy tongue, husky voice, jaundice, onycholysis, nail color change, fixed drug eruption, arthritis, kidney damage, interstitial nephritis, acute renal failure, oliguria, hematuria, vision impairment, papilledema of the optic disc, decreased and lost sense of smell and taste, vitamin K deficiency, vitamin B group deficiency symptoms, facial, tongue, and laryngeal edema, yellow urine, reduced urine glucose, liver and kidney parenchymal damage, anaphylactic reaction, liver damage, esophagitis, esophageal ulcer, hypersensitivity reaction

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It should be kept away from direct sunlight, ideally at a temperature between 1 and 30 degrees Celsius.

Appearance

It is a reddish-yellow, rectangular, film-coated tablet.

Package unit

100 tablets (10 tablets × 10)/PTP, 500 tablets/bottle