Medication info

Rifampin 600 mg (Rifampicin)

Prescription medicationOralApproval withdrawn
Ingredient · strength
Rifampicin›600mg / 1 tablet
Manufacturer / importer
Yuhan Corporation
Appearance
Pale reddish-brown elongated film-coated tablet
Packaging
100 tablets/bottle
Approval status
Approval withdrawn

MFDS item code 198300329 · Notified 1983.10.20

This product's status changed to Approval withdrawn on 2024.07.11. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Treatment of tuberculosis and asymptomatic carriers of meningococci
Who takes it
Adults · Children
Adult dose
1. Tuberculosis ○ Adults: Administer 450~600mg (potency) of rifampicin orally once daily. A dose of 450mg is recommended for patients weighing 50Kg or less, and 600mg for those weighing 50Kg or more. In principle, administer in combination with other antituberculosis drugs. 2. Asymptomatic meningococcal carriers ○ Adults: Administer 600mg (potency) of rifampicin orally twice daily for 2 days. It is preferable to take with plenty of water 1 hour before meals or 2 hours after meals. Adjust the dose appropriately according to age and symptoms.
Child dose
1. Tuberculosis ○ Children: Administer 10~20mg (potency) per Kg of body weight orally once daily. Do not exceed 600mg (potency) per day. ○ The dosage for children 5 years of age or younger has not been established; administer with caution. 2. Asymptomatic meningococcal carriers ○ Children (1~12 years): Administer 10mg (potency) per Kg of body weight orally twice daily for 2 days. ○ Infants (3~12 months): Administer 5 mg (potency) per Kg of body weight orally twice daily for 2 days.

Ingredients

Manufacturer
Yuhan Corporation

Efficacy & effects

Treatment of tuberculosis and asymptomatic carriers of meningococci

View approved original text

This medication is effective against tuberculosis and meningococcal bacteria. It is used in the treatment of tuberculosis patients and the management of asymptomatic carriers of meningococci.

How to take

Adult dose

1. Tuberculosis ○ Adults: Administer 450~600mg (potency) of rifampicin orally once daily. A dose of 450mg is recommended for patients weighing 50Kg or less, and 600mg for those weighing 50Kg or more. In principle, administer in combination with other antituberculosis drugs. 2. Asymptomatic meningococcal carriers ○ Adults: Administer 600mg (potency) of rifampicin orally twice daily for 2 days. It is preferable to take with plenty of water 1 hour before meals or 2 hours after meals. Adjust the dose appropriately according to age and symptoms.

Child dose

1. Tuberculosis ○ Children: Administer 10~20mg (potency) per Kg of body weight orally once daily. Do not exceed 600mg (potency) per day. ○ The dosage for children 5 years of age or younger has not been established; administer with caution. 2. Asymptomatic meningococcal carriers ○ Children (1~12 years): Administer 10mg (potency) per Kg of body weight orally twice daily for 2 days. ○ Infants (3~12 months): Administer 5 mg (potency) per Kg of body weight orally twice daily for 2 days.

Precautions

This medication can cause serious allergic reactions, so if symptoms such as fever, rash, or hives occur, seek medical attention immediately. Particular care should be taken as serious skin reactions may occur. Patients with biliary obstruction or severe liver disease, or those with an allergy to any components of this medication, should not take it. Additionally, it should not be administered to certain antiviral agents or to neonates and premature infants. Use cautiously in patients with impaired liver function or adrenal function and in those allergic to pigment components. Use of this medication may cause symptoms such as insomnia, headache, fatigue, dyspepsia, vomiting, and diarrhea; consult a doctor if any adverse effects persist. Regular blood tests are required as changes such as thrombocytopenia or leukopenia may occur. Periodic liver and kidney function tests are necessary due to the potential for impaired liver or kidney function. Respiratory symptoms or lung problems may arise, so notify healthcare providers immediately if shortness of breath or worsening cough occurs. This medication has many drug interactions that may reduce the effectiveness of some drugs or increase side effects, so inform your doctor of any medications you are taking. Particularly, the effectiveness of oral contraceptives may be diminished, so consult your doctor about contraceptive methods. Women who are pregnant or may become pregnant should avoid this medication, and breastfeeding women should also consider carefully. In case of overdose, symptoms such as vomiting, impaired consciousness, or seizures may occur, requiring immediate emergency treatment. This medication may cause urine, sweat, saliva, and tears to turn red, which is not a cause for concern. Tooth discoloration may be permanent, so thorough dental care should be maintained during the treatment period. If any unusual symptoms occur while taking this medication, inform healthcare providers immediately and follow their instructions.

Side effects

eosinophilia, fever, rash, hives, angioedema, hypotension, acute bronchospasm, conjunctivitis, thrombocytopenia, neutropenia, elevated liver transaminases, weakness, fatigue, myalgia, nausea, vomiting, headache, chills, pain, itching, sweating, dizziness, shortness of breath, chest pain, cough, syncope, palpitations, insomnia, anxiety, psychiatric symptoms, generalized malaise, headache, drowsiness, fatigue, ataxia, decreased concentration, mental confusion, convulsions, vertigo, hemorrhagic erosive gastritis, loss of appetite, nausea, vomiting, gastric pain, diarrhea, membrane colitis, bloody stools, severe colitis, abdominal pain, tooth discoloration, thrombocytopenia, leukopenia, granulocytopenia, bleeding tendency, hemolytic anemia, agranulocytosis, eosinophilia, vitamin K-dependent coagulation disorders, flushing, itching, hives, conjunctival injection, toxic epidermal necrolysis, lichenoid eruptions, pemphigus vulgaris lesions, exudative conjunctivitis, purpura, jaundice, transient AST elevation, transient ALT elevation, renal failure, interstitial nephritis, nephrotic syndrome, elevated BUN, elevated urea levels, proteinuria, hematuria, hemoglobinuria, hemolysis, flu-like syndrome, erythema multiforme, stomatitis, tongue pain, shock-like symptoms, interstitial lung disease, pulmonary inflammation, hypersensitivity pneumonitis, eosinophilic pneumonia, pulmonary infiltration, organic pneumonia, respiratory failure, pulmonary fibrosis, acute respiratory distress syndrome, heartburn, dyspnea, asthmatic attack, bronchial obstruction, interstitial pneumonia, visual disturbances, osteomalacia, muscle weakness, limb pain, menstrual disorders, unusual drug reactions, skin pigmentation, saliva discoloration, nasal discharge discoloration, sweat discoloration, facial pigmentation, tooth staining, thirst, hepatomegaly, acute pulmonary edema, dyspnea, altered consciousness, tachycardia, leg cramps, heart attack

Not everyone experiences these, and they can vary from person to person.

Storage

Store this medication in a tightly sealed container that is protected from light, as it is sensitive to light. It is important to maintain the storage temperature between 1 and 30 degrees Celsius. Proper storage ensures the medication's efficacy and safety.

Appearance and packaging

Appearance

Pale reddish-brown elongated film-coated tablet

Package unit

100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.