Udenolone Injection (Triamcinolone Acetonide)

Adult administration

1. Intra-articular, intra-bursal, intra-tendon injection: Adults: Triamcinolone Acetonide at a single dose of 2 to 40 mg, generally administered every 2 weeks or adjusted accordingly. 2. Intramuscular injection: Adults and children over 12: Typically for the initial dose, 40 mg is deeply injected into the gluteal muscle and adjusted within 20 to 80 mg at 1 to 2 week intervals based on the patient's therapeutic effect.

Child administration

Intramuscular injection 6 to 12 years old: A starting dose of 40 mg is appropriate and adjusted according to age, body weight, and symptoms. Children under 6 years are not recommended.

This medication is in suspension form and should not be administered via intravenous injection. Injection into the epidural space or spinal canal is also prohibited, as serious side effects may occur in those areas. This drug should not be used in patients with allergies to it or its components. It can worsen the condition in patients with infections or systemic fungal infections due to its immune-suppressive effects, hence it must not be administered. Caution is also needed in patients with thrombocytopenia, purpura, herpes simplex, herpes zoster, and chickenpox. It is advisable not to administer if there are infections around the joints, bursae, or tendons, as it may exacerbate the condition. In patients with unstable joints, the symptoms may worsen. Patients with specific diseases must use this drug cautiously. Caution is warranted in patients with tuberculosis, keratitis, cataracts, glaucoma, hypertension, electrolyte imbalances, thrombosis, and history of myocardial infarction due to the risk of side effects. Patients recovering from surgery, those with peptic ulcers, mental disorders, or osteoporosis should also be treated with caution. Patients with infectious diseases, hypothyroidism, liver disease, renal failure, congestive heart failure, and diabetes also require careful monitoring due to the potential for worsening conditions. Various side effects may occur during the use of this medication; thus, the patient's condition should be monitored closely. Imbalances of bodily fluids and electrolytes, hypertension, and edema, as well as muscle pain, osteoporosis, and increased risk of fractures may arise. Gastrointestinal issues such as stomach ulcers, nausea, vomiting, and appetite changes may occur. Skin issues like delayed wound healing, rash, and hair loss can also appear. Neurological issues such as headaches, dizziness, insomnia, and seizures have been reported, and in severe cases, spinal injury may be a concern. The endocrine system and eye health can also be affected, necessitating regular examinations. Abnormalities in the blood and metabolic systems, respiratory deterioration, and shock reactions may occur; hence caution is required. This medication can interact with other drugs, so it is vital to notify any medications being taken concurrently. In particular, concomitant use with drugs that affect enzymes involved in drug metabolism in the liver may increase the risk of side effects. Dose adjustment and monitoring are necessary when used alongside non-steroidal anti-inflammatory drugs, anticoagulants, and diuretics. Pregnant women or those who may become pregnant should consult with a physician, as this medication may pose risks to the fetus. It is advisable to discontinue breastfeeding while using this drug, as it may transfer into breast milk. In children, side effects such as growth retardation may occur; therefore, the minimum dosage should be administered cautiously, and prolonged use can lead to issues like increased intracranial pressure. Elderly patients have a higher risk of side effects such as infections, diabetes, and osteoporosis; thus, they should be used under careful observation. When administering, avoid specific routes such as intravenous injection, spinal injection, or epidural injection, and during intramuscular injections, avoid injecting near nerves or blood vessels. If pain or blood reflux occurs during the injection, the injection site should be changed immediately.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, breathing difficulties, cold sweat, pallor, high fever accompanied by severe rash, blistering, skin peeling, pain of oral/ocular mucous membranes, breathlessness or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), severe and sudden fatigue, sudden and very severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis,

Mild side effects

• Muscle pain
• joint pain
• muscular weakness
• fatigue
• myopathy
• muscle mass loss
• osteoporosis
• vertebral compression fractures
• delayed bone healing
• aseptic necrosis

This medication is sensitive to light and must be stored in a container that does not allow light to enter; it is safe to store at room temperature between 1 and 30 degrees Celsius. Therefore, it is crucial to avoid direct sunlight and not to place it in excessively hot or cold environments.

Appearance

A white vial preparation containing a white suspension injection.

Package unit

1 mL/each [(1 mL x 50 vials)]