International Doxycycline Hyclate Hydrate Capsule 100 mg

Adult dose

○ Adults: The initial dose of doxycycline is 100 mg (potency) per dose, administered orally every 12 hours. The maintenance dose is 100 mg (potency) per day, administered in 1 ∼ 2 divided doses. ○ For severe infections, administer the initial dose every 12 hours. This medicine should be continued for 24 ～ 48 hours after symptoms have subsided and fever has resolved. For streptococcal infections, continue treatment for at least 10 days to prevent the onset of rheumatic fever or glomerulonephritis. Adjust the dose as appropriate according to age and symptoms.

Child dose

○ Adolescents aged 12 years and older weighing 45 kg or less: The initial dose is 4 mg (potency) per kg of body weight per day, administered orally in 2 divided doses. The maintenance dose is 2 mg (potency) per kg of body weight per day, administered in 1 ∼ 2 divided doses. ○ Adolescents aged 12 years and older weighing more than 45 kg: Administer a dose equivalent to the adult dose.

This medication can cause diarrhea due to Clostridium difficile, which can range from mild to severe colitis. If diarrhea symptoms appear after antibiotic use, testing is required, and caution is necessary if symptoms develop more than 2 months after medication. Serious skin reactions may occur during use; therefore, if skin rashes, red spots, or mucosal damage appear, discontinue use immediately and seek medical attention. It is advisable for pregnant women, breastfeeding mothers, children under 12, patients with severely impaired kidney or liver function, and those with certain muscle weakness conditions to avoid taking this medication. Caution is particularly necessary in children and during late pregnancy due to the potential for tooth discoloration and growth impairment. Patients with reduced kidney function may have increased drug concentration leading to a higher risk of side effects, so dosage adjustment and blood concentration tests are necessary. This medication increases skin sensitivity to sunlight, which may result in severe sunburn, so it is recommended to avoid direct sunlight and use sunscreen. To prevent esophageal irritation and ulcers, take the medication with sufficient water while standing or sitting and avoid lying down immediately. Regular monitoring of major organ functions, such as liver, kidney, and hematopoietic system, is essential during prolonged use to identify any abnormalities. This medication may interact with other drugs, so it is important to inform healthcare providers of any concurrent medications, especially oral contraceptives, as their effectiveness may be reduced. In case of overdose, symptoms such as vomiting, liver and kidney damage, and esophagitis may occur; seek medical attention immediately for appropriate treatment. Store this medication in a tightly sealed container out of reach of children.

Diarrhea due to Clostridium difficile, colitis, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reactions accompanied by eosinophilia and systemic symptoms, hemolytic anemia, neutropenia, thrombocytopenia, hypersensitivity, anaphylactic shock, angioedema, exacerbation of systemic lupus erythematosus, pericarditis, serum sickness, Henoch-Schönlein purpura, hypotension, dyspnea, tachycardia, peripheral edema, urticaria, microscopic brown discoloration of the thyroid gland, decreased appetite, headache, benign intracranial hypertension, protruding fontanelle, tinnitus, flushing, nausea, vomiting, dyspepsia, pancreatitis, pseudomembranous colitis, esophageal ulcer, esophagitis, small intestine and colitis, inflammatory lesions around the anal and genital area, dysphagia, abdominal pain, diarrhea, glossitis, tooth discoloration, hepatotoxicity, hepatitis, abnormal liver function, photosensitivity reactions, rash, exfoliative dermatitis, photo-induced onycholysis, arthralgia, myalgia, increased BUN, anemia, granulocytopenia, atypical lymphocytes, lymphocytopenia, lymphadenopathy, blood coagulation disorders, fever, sensory disturbances, anxiety, restlessness, severe colitis accompanied by bloody stools, loose stools, stomatitis, sore throat, black hairy tongue, hoarseness, jaundice, onycholysis, changes in nail color, fixed drug eruption, arthritis, kidney damage, interstitial nephritis, acute renal failure, oliguria, hematuria, visual disturbances, papilledema of the optic nerve head, decreased and loss of smell and taste, vitamin K deficiency, vitamin B deficiency symptoms, swelling of the face, tongue and larynx, yellow urine, reduced glycosuria, damage to liver and kidney parenchyma, anaphylactic reaction, liver damage, pancreatitis, esophagitis, esophageal ulcer

This medication should be stored in a closed container to protect it from air and moisture. This will help maintain the effectiveness of the medication and prevent deterioration.

Appearance

Hard capsule with a yellow powder, upper part black, lower part white

Package unit

30 capsules/bottle, 100 capsules/bottle, 1000 capsules/bottle