Yuyu Allopurinoljeong

Adult dose

○ Adults Because a rapid decrease in serum uric acid levels may sometimes precipitate an acute gout attack, begin with a low dose (allopurinol 100 mg once daily) and increase by 100 mg each week until the serum uric acid level is 7 mg/100 mL in men and postmenopausal women or 6 mg/100 mL in premenopausal women. Do not exceed 800 mg per day; administer orally. The usual adult dose of allopurinol is 100 ∼ 300 mg per day for mild gout, 300 ∼ 600 mg per day for moderately severe tophaceous gout, and 600 ∼ 800 mg per day for severe tophaceous gout. Administer orally after meals in 1 ∼ 3 divided doses (not exceeding 300 mg per dose). ○ In patients with renal impairment, reduce the dose according to creatinine clearance. If creatinine clearance is 10 ～ 20 mL/min, administer 100 ～ 200 mg per day; if it is less than 10 mL/min, administer no more than 100 mg per day in 1 ∼ 3 divided doses or at longer intervals. If plasma oxypurinol levels can be measured, adjust the dose to maintain the plasma oxypurinol level at or below 100 μmol/L(15.2 mg/L).

This medication can cause serious allergic reactions on the skin during treatment. Such reactions can be life-threatening, so if skin rash or other abnormal symptoms occur, the medication should be stopped immediately. This medication should not be used in children, nursing mothers, individuals with allergies to this medication, those who have experienced severe adverse reactions, patients with mild hyperuricemia who are asymptomatic, and patients with certain genetic disorders. Patients with liver or kidney problems, pregnant women, the elderly, and those taking specific medications should use this medication cautiously and require regular testing. Various adverse reactions such as skin rash, fever, and joint pain may occur during the use of this medication, and in severe cases, liver dysfunction, kidney issues, pneumonia, and muscle damage may also occur, so immediate consultation with a doctor is necessary if symptoms appear. This medication may interact with other drugs, so if there are other medications being taken, it is important to inform a doctor or pharmacist, as dosage adjustments or further testing may be necessary. Pregnant or nursing women should be cautious when using this medication, and it is advisable to avoid use while nursing. The safety of this medication has not been established in children, so caution is necessary when using it. Elderly patients may require dosage adjustments due to increased drug concentration from decreased kidney function. It is advisable to maintain adequate hydration and increase urine output during the use of this medication to reduce kidney strain. Keep this medication out of the reach of children and store it in its original container to prevent misuse and degradation of quality.

Hypersensitivity syndrome (DRESS), Stevens-Johnson syndrome (mucocutaneous syndrome), toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis, hypersensitivity vasculitis, eosinophilia, epidermal detachment, fever, lymphadenopathy, arthralgia, hepatitis, renal dysfunction, seizures, shock, anaphylactic-like symptoms, aplastic anemia, pancytopenia, agranulocytosis, severe liver dysfunction, hepatic necrosis, granulomatous hepatitis, jaundice, renal failure, worsening of renal failure, interstitial nephritis, interstitial pneumonia, cough, dyspnea, rhabdomyolysis, myalgia, malaise, elevated creatine kinase, elevated serum and urinary myoglobin, stomatitis, diarrhea, convulsions, loss of appetite, abdominal discomfort, steatorrhea, hematemesis, renal dysfunction, interstitial nephritis with lymphocytic infiltration, xanthine stones, taste disturbances, visual disturbances, peripheral neuropathy, peripheral neuritis, headache, ataxia, leukopenia, thrombocytopenia, thrombocytopenic syndrome, eosinophilia, angioimmunoblastic lymphadenopathy, fever, skin rash, vasculitis, lymphadenitis, pseudolymphoma, hepatosplenomegaly, abnormal liver function tests, cholestatic liver disease, pruritus, gynecomastia, dizziness, hyperlipidemia, furunculosis, angina pectoris, hypertension, bradycardia, uremia, hematuria, angioedema, hair loss, increased thyroid-stimulating hormone, drowsiness

This medication must be stored in a tightly sealed container to protect it from air and moisture. This will help maintain the medication's efficacy and prevent it from deteriorating.

Appearance

White round tablet

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 100 tablets/bottle, Bottle packaging - 180 tablets/bottle