Yuhan Pyrazinamide Tablet 250 mg (Pyrazinamide)

Adult dose

Adults: Administer 1.5～2.0 g of pyrazinamide per day (maximum 3 g per day) orally in 1～3 divided doses. In principle, administer concomitantly with other antituberculosis drugs. Adjust the dose appropriately according to age and symptoms.

It is important not to use this medication in certain patients. For example, individuals allergic to this medication or its components, those with liver or kidney function issues, patients with hyperuricemia, porphyria patients, and pregnant or nursing women should not take this medication. Additionally, individuals with a history of gout attacks or elevated uric acid levels, patients suspected of having liver or kidney function problems, the elderly, diabetics, and those allergic to certain medications should use this medication cautiously. When taking this medication, liver-related problems such as abnormal liver function, hepatitis, or jaundice may occur, so regular monitoring of liver status is necessary. Also, symptoms such as gout attacks, myalgia, blood abnormalities, hypersensitivity reactions like fever or rash, dyspepsia, nephritis may occasionally appear, and immediate consultation with a doctor is required if any symptoms occur. Long-term or unnecessary use of this medication may lead to drug resistance, so it is advisable to perform susceptibility testing and take it for the minimum necessary duration. If symptoms worsen or new symptoms appear during treatment, it may be a paradoxical drug reaction which requires medical diagnosis and management. When taken with other anti-tuberculosis agents or medications that may burden the liver, frequent liver function tests are required, and this medication can reduce the efficacy of certain drugs or affect their blood concentrations, so caution is advised when used in combination. Pregnant women or those who might become pregnant, as well as nursing women, are recommended to avoid this medication, and if it is absolutely necessary, breastfeeding should be discontinued. Safety for pediatric use has not yet been established, so it should be used cautiously in children, and elderly patients should be closely monitored due to potentially weakened body functions. In case of overdose, hepatotoxicity and hyperuricemia may occur, and since there is no specific antidote, gastric lavage and supportive treatment may be necessary. Depending on the symptoms, additional medication may be needed, so immediate medical assistance should be sought.

• Hepatitis
• jaundice
• hepatomegaly
• splenomegaly
• elevation of AST/ALT
• porphyria
• increased uric acid levels
• gout attacks
• arthralgia
• myalgia

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and it does not require special refrigeration; it can be stored at room temperature.

Appearance

It is a white round tablet.

Package unit

30 tablets/bottle, 500 tablets/bottle