Dopramine Injection (Dopamine Hydrochloride)

Adult administration

As dopamine hydrochloride, it is administered intravenously at a dose of 2-5μg/min per kg of body weight. In severe cases, the dose can be increased from 5-10μg/min to 20-50μg/min per kg of body weight and administered intravenously. Adjust the dose according to age and symptoms.

When using this medication, be careful to cut the ampoule to minimize the risk of glass fragments entering it. Extra caution is required when using it for children or the elderly. This medication should not be used in patients with certain conditions. For example, it should not be administered to patients with pheochromocytoma, tachyarrhythmias, ventricular fibrillation, hyperthyroidism, or angle-closure glaucoma. Patients with peripheral vascular disorders or allergies to sulfites should use this medication with caution. People sensitive to sulfites may experience allergic reactions such as asthma attacks, so attention is needed. This medication may cause cardiac-related side effects, so heart rhythm abnormalities and blood pressure changes should be carefully monitored. If peripheral blood vessels constrict, causing cold or discolored hands and feet, administration should be stopped and appropriate treatment must be taken. Gastrointestinal symptoms such as nausea, vomiting, and abdominal pain may occur, and in rare cases, serious problems such as intestinal obstruction may arise. Headaches or anxiety may occur, and there is a possibility of inflammation or tissue damage at the injection site. When administering this medication, sufficient consideration should be given to the patient's blood volume and heart function status, and if needed, fluid or blood supplementation and respiratory management should be performed alongside. If the pulse suddenly slows, the dosage should be reduced, and the patient should be observed closely while monitoring blood pressure and urine output attentively. Care should be taken regarding interactions when using with other medications. Specifically, when combined with certain anesthetics, antidepressants, or drugs affecting the sympathetic nervous system, it may cause cardiac stimulation or blood pressure changes, so caution is warranted. Women who are pregnant or may become pregnant should only use this medication when the therapeutic benefits are considered to outweigh the risks, and during breastfeeding, administration should be avoided if possible or breastfeeding should be discontinued. Safety and efficacy have not been established for pediatric patients, so use should be avoided. Elderly patients may experience side effects more easily due to decreased body function, so it is essential to start with a lower dose and carefully monitor their condition during administration. If the medication leaks at the injection site, tissue necrosis may occur, so it is essential to administer it into a large vein and closely observe the condition of the injection site. This medication may lose effectiveness if mixed with alkaline solutions, so it should not be mixed with alkaline solutions, and after dilution, it should be used within 24 hours.

Serious side effects

• Shortness of breath → Breathing problems
• Increased blood pressure → Severe edema or urination problems

Mild side effects

• Ventricular ectopy, atrial fibrillation, ventricular tachycardia, and other arrhythmias
• Changes in color and temperature of extremities due to peripheral vascular constriction
• Tachycardia, angina, palpitations, shortness of breath, hypotension, abnormal conduction, bradycardia, increased QRS duration, hypernitrogenemia, increased blood pressure
• Nausea, vomiting, abdominal distension, abdominal pain, paralytic ileus
• Headaches, anxiety, phlebitis, degeneration necrosis at the injection site and hair loss

This medication may be sensitive to light, so it should be stored in a sealed container that does not allow light in. Additionally, when storing the medication, it is crucial to maintain a room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

A transparent liquid that is colorless to light yellow, packaged in brown transparent ampoules as an injectable solution

Package unit

5mL/ampoule × 50