Dae Han 50% Dextrose Injection

Adult administration

Administer 20-500 mL via intravenous injection once. The rate of intravenous infusion should be no more than 0.5 g/kg of glucose per hour. Use an appropriate amount for reconstitution or dilution of the injection. Adjust according to age and symptoms.

Care must be taken when cutting the vial of this ampoule injection as glass fragments may mix in, especially using it in children or the elderly. Patients receiving intravenous injections of this medication may rapidly deplete vitamin B1 (thiamine), leading to a fatal deficiency, so caution is necessary. This medication should not be administered to patients with storage dehydration, fluid overload, hyperglycemia, acidosis, hypokalemia, hyperosmolar coma, glucose intolerance, anuria, hepatic coma, or similar conditions. It should be avoided in patients with intrathecal bleeding, intracranial bleeding, or tremulous delirium. In patients with severe dehydration, administering a hyperosmotic glucose solution should be avoided as it may worsen the hyperosmolar state. It must be administered with caution in patients with tendencies toward potassium, phosphate, or magnesium deficiency, hyponatremia, diabetes insipidus, renal failure, heart failure, severe malnutrition, thiamine deficiency, sepsis, severe or trauma patients, and shock state. In cases of diabetes or when hypertonic solutions are required, administration should be closely monitored for blood glucose control and patient condition. Rapid large-volume administration may cause electrolyte imbalance or fluid overload, so attention should be paid to the rate and dosage of administration. Excessive administration can increase bilirubin and lactate levels and may lead to side effects such as hypokalemia, acidosis, dehydration, hyperosmolarity, and polyuria. When administered via intravenous injection, fluid imbalance, congestion, pulmonary edema, phlebitis, thrombosis, and pain at the injection site may occur, so caution is required. This medication may affect insulin secretion with prolonged use, necessitating insulin supplementation if needed. In postoperative or post-trauma situations, it is safer to use a 5% solution while closely monitoring blood glucose control. Regular checks of serum electrolyte and fluid balance, and blood glucose levels are essential, and patient condition should be continuously monitored. Its safety during pregnancy has not been established; thus, the risks to the fetus and therapeutic effects should be carefully considered before administration. When administered during childbirth, both the mother and newborn are at risk for hyperglycemia and hypoglycemia, requiring monitoring. In children, especially low birth weight or premature infants, fluid and electrolyte regulation may be impaired, necessitating close observation of blood glucose and electrolyte levels. Elderly patients are at a higher risk of side effects due to decreased bodily function, so careful attention is necessary during administration. Overdosage may lead to hyperglycemia and symptoms of diabetes, requiring appropriate treatment such as insulin administration. Subcutaneous injections may cause circulatory failure due to electrolyte movement in the plasma and are associated with significant local irritation, thus should be avoided. After opening, use immediately and discard any remaining solution, with caution regarding infection risk during injection. During storage, it is advisable to keep it warm at room temperature, between 1 to 30 degrees Celsius. Caution is advised during administration of hypertonic solutions due to the risk of thrombophlebitis. Abrupt cessation of administration may induce hypoglycemia, thus it should be tapered off gradually. When administered simultaneously with blood, agglutination reactions may occur, therefore they should not be given together. When mixing with other medications, it is essential to have a thorough understanding of potential chemical and physical side effects, carefully observe, and use immediately. Caution should also be exercised regarding interactions with the container or stopper, and continuous connection during administration should be avoided to prevent air embolism.

Mild side effects

Hypokalemia, acidosis, dehydration, hyperosmolarity, diabetes mellitus associated with glucose excretion, phlebitis, thrombosis, blood leakage, injection site pain, uremia, excessive blood or fluid states, fluid-electrolyte imbalance, congestion, pulmonary edema, fever

This medication should be stored in a sealed container to avoid contact with air and kept at temperatures between 1 to 30 degrees Celsius to maintain its effectiveness and prevent deterioration.

Appearance

A colorless to pale yellow transparent liquid with a sweet taste, filled in ampoules or glass containers or plastic bags for infusion.

Package unit

20 mL/ampoule, 100 mL/bottle, 500 mL/bottle, 500 mL/bag