Jungwoo 20% Mannitol Injection

Key information summary

Efficacy & effects

This medication is used to prevent and treat acute kidney failure that may occur during or after surgery, and after trauma. It also promotes the excretion of toxins from the body in cases of drug overdose. This medication can be used to lower intracranial pressure when there is increased brain pressure or when a reduction in brain volume is needed. Additionally, it is effective for ophthalmic conditions such as glaucoma where lowering intraocular pressure is necessary. Thus, it is used to protect kidney function, remove toxins from the body, and regulate the pressure in the brain and eyes in several situations.

Dosage

D-mannitol is usually administered intravenously as a drip at a dose of 1 to 3 g per kilogram of body weight in 15% or 20% solutions. The maximum daily dose is up to 200 g. The infusion rate is 100 mL over 3 to 10 minutes. It should be adjusted appropriately based on age and symptoms.

Precautions

This medication should not be administered to patients with acute intracranial hematoma or cerebral hemorrhage. It should also not be used in patients with severe congestive heart failure, dehydration, or in patients who have imbalances in fluids and electrolytes. Avoid administration in patients with pulmonary edema or pulmonary congestion, as well as those with metabolic edema. It is contraindicated in patients with anuria or hypersensitivity to this drug, as well as in patients who are tense or overly tensed. Furthermore, this medication should not be used in patients who have low urine output or persistent anuria after trial administration, nor in patients with severe hypovolemia. This medication should be administered cautiously in patients with renal dysfunction, particularly those with urinary retention or diabetic nephropathy, and patients whose kidney function has deteriorated due to heart or liver diseases. Care must also be taken with patients who have cranial injuries, children under 12 years, pregnant women, elderly patients, and those with hypervolemia. When administering this medication, be cautious as symptoms of cardiovascular abnormalities such as chest tightness, angina, tachycardia, and changes in blood pressure may occur. Symptoms of changes in intracranial pressure such as headaches, nausea, vomiting, and dizziness may also occur. With high doses, acute kidney failure may develop, so renal function must be closely monitored. Fluid and electrolyte imbalances may develop, and metabolic acidosis can occur with overdose. Patients with a history of allergies may experience severe hypersensitivity reactions or anaphylaxis, so they should be monitored closely during administration. Due to electrolyte disturbances, symptoms such as hypotension and edema may occur, requiring immediate cessation of administration and appropriate treatment if these symptoms arise. This medication should be discontinued in cases of deteriorating kidney, heart, or lung function, and high-dose administration may lead to central nervous system toxicity. Watch for symptoms such as phlebitis, pain, or rash at the infusion site, and ensure that the solution does not leak outside the vessel. Before administration, it is advisable to conduct a load test to assess kidney function, and if function is insufficient, administration should be terminated. Continuous monitoring of fluid and electrolyte status, blood pressure, and intracranial pressure is necessary during administration. This medication may increase the risk of renal failure when used with other diuretics or nephrotoxic drugs, so co-administration should be avoided. If used with lithium, blood concentration and signs of toxicity should be monitored frequently. The safety of this drug during pregnancy has not been established, so it should only be administered when the therapeutic benefit outweighs the risk, and it is preferable not to administer it to nursing mothers. In elderly patients, the risk of side effects is increased due to diminished kidney function, so comprehensive evaluation of kidney, heart, and lung conditions is required before administration. In the event of overdose, symptoms such as rapid dehydration, acute kidney failure, hypervolemia, and heart failure may occur, requiring immediate appropriate treatment in response to any symptoms. This medication is administered solely through intravenous drip, and the addition of sodium chloride or potassium chloride may cause precipitation, so the condition of the solution must be carefully checked. During administration, handling of urination must be thorough due to the strong diuretic effect, and care must be taken to prevent the solution from leaking outside the vessel.

Side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin abnormal reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and severe

Alternatives / Same-ingredient medications

• Chungwoo 15% Mannitol Injection

  Same ingredient
• DaeHan D-Mannitol Injection (15%)

  Same ingredient

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