Macperan Tablet (Metoclopramide)

Adult dose

Even if vomiting occurs or a dose is refused, an interval of at least 6 hours between doses is recommended. (Oral) 1. Adults: Administer 10-30mg of metoclopramide hydrochloride (equivalent to 7.7-25.4mg of metoclopramide) per day orally in 2-3 divided doses before meals. The maximum recommended daily dose is 30mg or 0.5mg per kg of body weight, and the maximum recommended duration of treatment is 5 days. The maximum duration of treatment for prevention of delayed nausea and vomiting after chemotherapy is 5 days. 3. Elderly patients: Dose reduction should be considered based on renal and hepatic function and overall frailty. 4. Patients with renal impairment: For patients with end-stage renal disease (creatinine clearance ≤ 15ml/min), the daily dose should be reduced by 75%. For patients with moderate to severe renal impairment (creatinine clearance 15～60 ml/min), the dose should be reduced by 50%. 5. Patients with hepatic impairment: For patients with severe hepatic impairment, the dose should be reduced by 50%.

Child dose

2. Children: The recommended dose is 0.1～0.15mg per kg of body weight, repeated up to 3 times daily. The maximum dose within 24 hours is 0.5mg per kg of body weight. 1-3 years, 10-14kg: Single dose 1mg, up to 3 times daily 3-5 years, 15-19kg: Single dose 2mg, up to 3 times daily 5-9 years, 20-29kg: Single dose 2.5mg, up to 3 times daily 9-18 years, 30-60kg: Single dose 5mg, up to 3 times daily 15-18 years, over 60kg: Single dose 10mg, up to 3 times daily This medicine is contraindicated in children under 1 year of age.

This medication may cause serious side effects called tardive dyskinesia if used for a long time or in high doses, so it is advisable not to use it for longer than 3 months. This medication should not be used in patients with certain conditions, such as pheochromocytoma, gastrointestinal bleeding or obstruction, or those with Parkinson's disease. It should not be administered to children under 1 year of age or patients with hereditary lactose intolerance. Special precautions should be taken when using this medication in children, adolescents, the elderly, or patients with impaired kidney or liver function, and overdosing should be avoided while closely monitoring the patient's condition. While taking this medication, rare adverse reactions such as allergic reactions, severe muscle rigidity, changes in blood pressure, fever, extrapyramidal symptoms (tremors, muscle stiffness, etc.), gastrointestinal symptoms (abdominal pain, diarrhea, etc.), central nervous system symptoms (drowsiness, headache, anxiety, etc.), and seizures may occur; hence, immediate consultation with a doctor is required if abnormal symptoms appear. Patients with heart disease or conduction disorders should be particularly cautious, and when administering this medication intravenously, the heart condition should be closely monitored. This medication can interact with other drugs, so it is essential to inform healthcare professionals about any currently taken medications, especially when combined with neuroleptics, antidepressants, anticonvulsants, digitalis preparations, etc. It should only be used during pregnancy when necessary, and during late pregnancy, it is advisable to avoid administration to prevent any adverse symptoms in the newborn. During breastfeeding, since this medication can be excreted into breast milk, alternatives should be considered, or breastfeeding should be discontinued. Elderly patients should have their dosage adjusted and check for side effects carefully since renal function may be impaired, leading to drug accumulation in the body. In the case of overdose, symptoms such as drowsiness, confusion, severe movement disorders, and cardiopulmonary arrest may occur, necessitating an immediate visit to the hospital for appropriate treatment. It is safe to avoid hazardous activities such as driving or operating machinery while taking this medication.

Dystonia, shock, anaphylactic symptoms, motor paralysis, muscle rigidity, dysphagia, aphasia, tachycardia, changes in blood pressure, sweating, leukocytosis, elevated serum CPK levels, myoglobinuria, renal dysfunction, high fever, altered consciousness, dyspnea, circulatory collapse, dehydration symptoms, acute renal failure, amenorrhea, persistent lactation, gynecomastia, hand tremor, muscle stiffness, tonic-clonic contractions of the neck and shoulders, ocular rotation seizures, agitation, involuntary movements around the mouth, increased tension in the stomach, abdominal pain, diarrhea, constipation, hypotension, arrhythmia, headache, heaviness in the head, drowsiness, excitement, anxiety, convulsions, fatigue, rash, edema, methemoglobinemia, hyperbilirubinemia, bradycardia, cardiac arrest, atrioventricular block, sinus arrest, prolonged QT interval on electrocardiogram, polymorphic ventricular tachycardia, hyperprolactinemia, excessive milk secretion, gynecomastia, weakness, hypersensitivity, anaphylactic reactions, drowsiness, extrapyramidal disorders, Parkinsonism, restlessness, muscle tone disorders, abnormal movements, decreased consciousness, seizures, neuroleptic malignant syndrome, depression, hallucinations, confusion, hypotension, acute hypertension, shock, syncope, nausea, vomiting, paresthesia, chest pain, confusion

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. Additionally, it is recommended to store it at normal indoor temperatures, avoiding excessively hot or cold places.

Appearance

White round film-coated tablet

Package unit

100 tablets/bottle, 1000 tablets/bottle