Medication info

DaeHan Aminophylline Injection (2.5%)

Prescription medicationInjectionsIntravenous injection
Ingredient · strength
Aminophylline Hydrate›25mg / 1mL
Manufacturer / importer
Daehan Pharmaceutical Co., Ltd.
Appearance
Brown glass ampoule injection containing a colorless, transparent liquid
Packaging
10ml × 50 ampoules
Approval status
Active

MFDS item code 197100030 · Notified 1971.12.15 · Insurance code 645100721

Summary

Main use
Relief of dyspnea; treatment of heart failure and Cheyne–Stokes respiration; prevention of cardiac asthma attacks
Who receives it
Adults
Adult administration
Adults: 250 mg of aminophylline hydrate per dose, diluted in normal saline injection or glucose injection, is administered slowly by intravenous injection or intravenous infusion over 5 ∼ 10 minutes, 1 ∼ 2 times daily. Allow an interval of at least 8 hours between doses. The maximum dose is 12 mg/kg of body weight per day. Adjust the dose as appropriate according to symptoms.

Ingredients

Manufacturer
Daehan Pharmaceutical Co., Ltd.

Efficacy & effects

Relief of dyspnea; treatment of heart failure and Cheyne–Stokes respiration; prevention of cardiac asthma attacks

  • Dyspnea due to airway obstruction
  • bronchial asthma
  • asthmatic bronchitis
  • emphysema
  • chronic bronchitis
  • congestive heart failure
  • cardiac asthma
  • Cheyne-Stokes respiration
View approved original text

This medication is used to relieve various symptoms such as dyspnea due to airway obstruction disorders like bronchial asthma, asthmatic bronchitis, emphysema, and chronic bronchitis. It also helps in preventing attacks in congestive heart failure and improves Cheyne-Stokes respiration. In summary, this drug is effective in improving symptoms caused by respiratory-related diseases and cardiac dysfunction.

How it is given

Adult administration

Adults: 250 mg of aminophylline hydrate per dose, diluted in normal saline injection or glucose injection, is administered slowly by intravenous injection or intravenous infusion over 5 ∼ 10 minutes, 1 ∼ 2 times daily. Allow an interval of at least 8 hours between doses. The maximum dose is 12 mg/kg of body weight per day. Adjust the dose as appropriate according to symptoms.

Precautions

The blood concentration of this medication should be periodically monitored to adjust the appropriate dose. If the blood concentration is too high, serious side effects such as seizures or cardiac rhythm abnormalities may occur. Patients with heart diseases should use this medication with special caution. When using glass ampoule injections, care should be taken to avoid contamination with glass shards, especially when administering to children or the elderly. Patients who are allergic to this medication or its components, or who have previously experienced serious side effects, should not receive it. It is also safe not to use this medication for patients with specific conditions such as gastric or duodenal ulcers, porphyria, acute tachyarrhythmia, or myocardial infarction. This medication should be used cautiously in certain patient groups, including those with epilepsy, hyperthyroidism, renal or liver dysfunction, hypertension, the elderly, pregnant women, and breastfeeding mothers, and should be used under a doctor's guidance. This drug may cause various side effects, such as headache, insomnia, dizziness, palpitations, nausea, and skin rashes. If any unusual symptoms occur, inform the medical staff immediately. When used with other medications, interactions may occur, so it is important to inform the medical staff of all medications being taken and to manage them carefully. Pregnant or breastfeeding women should consult with a doctor regarding the potential effects on the fetus or infant before using this medication. It is advisable not to administer this medication to infants under 6 months of age, and dose adjustments and condition monitoring are needed for children and the elderly. Rapid intravenous injection of this drug can increase the risk of side effects, so it should be diluted and administered slowly. In case of overdose, serious symptoms such as vomiting, seizures, and heart abnormalities may occur, requiring immediate emergency care and control of blood concentration with appropriate treatment. Since the management of blood concentration is very important for this drug, periodic testing is necessary, and medical staff should be consulted immediately if any adverse reactions occur.

Side effects

  • Cramps
  • supraventricular tachycardia
  • shock
  • headache
  • insomnia
  • central nervous system excitement
  • anxiety
  • dizziness
  • tinnitus
  • tremor
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  • paralysis
  • delirium
  • coma
  • palpitations
  • ectopic beats
  • flush
  • facial pallor
  • tachycardia
  • arrhythmia
  • hypotension
  • nausea
  • vomiting
  • loss of appetite
  • abdominal pain
  • dyspepsia
  • diarrhea
  • abdominal distension
  • gastric irritation
  • rash
  • itching
  • proteinuria
  • elevated serum uric acid levels
  • hypophosphatemia
  • hyponatremia
  • increased respiratory rate
  • rhabdomyolysis
  • elevated ALT
  • elevated AST
  • elevated ALP
  • edema

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light, so it should be stored in a sealed container that blocks light. Storing it this way helps maintain the drug's efficacy for a longer period.

Appearance and packaging

Appearance

Brown glass ampoule injection containing a colorless, transparent liquid

Package unit

10ml × 50 ampoules

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.