Septrin Tablets

Adult dose

For adults and children over 12 years old, orally administer 2 tablets as a single dose, twice a day, 12 hours apart after meals. For prolonged administration beyond 14 days, use a maintenance dose of 1 tablet as a single dose, twice daily, and in cases of severe infections, up to a maximum dose of 3 tablets in one dose.

Child dose

For children under 12 years old, administer trimethoprim 6 mg and sulfamethoxazole 30 mg divided into two doses daily per kg of body weight. For ages 6-11 years: 1 tablet per dose, 2 doses a day. For ages 3-5 years: 1/2 tablet per dose, 2 doses a day.

This medication can cause serious side effects such as severe skin reactions, blood disorders, and respiratory hypersensitivity, so if symptoms such as skin rash, fever, or sore throat occur during use, the medication should be stopped immediately. Life-threatening immune responses have been reported in patients taking this medication; if such symptoms are suspected, administration should be stopped immediately and a physician consulted. It should not be used for pharyngitis caused by Streptococcus, and it is especially contraindicated in newborns, pregnant women, nursing mothers, patients with certain blood disorders, and those with severely impaired liver or kidney function. Patients with a history of blood disorders or allergic predisposition, those with weak liver or kidney function, elderly patients, and those with thyroid dysfunction should use this medication with caution. Various blood abnormalities, skin rashes, liver function impairment, kidney dysfunction, neurological symptoms, and gastrointestinal disturbances may occur as side effects, so any abnormal symptoms during use should be reported to a physician immediately. It is important to conduct regular check-ups such as blood tests, liver function tests, and kidney function tests to detect and manage adverse reactions early. This medication has many interactions with other drugs, and side effects may be exacerbated depending on the medications being taken concurrently; therefore, it is essential to inform a physician or pharmacist of any other medications being taken. Women who are pregnant or may become pregnant, and nursing mothers, should not take this medication, and it should not be administered to newborns or infants under 2 months of age. Elderly patients may experience prolonged effects due to reduced kidney function, which may worsen side effects, so careful monitoring and dosage adjustments are necessary. Overdosage may cause vomiting, diarrhea, headache, altered consciousness, and blood abnormalities; therefore, adherence to the prescribed dosage is critical, and in case of overdose, immediate medical attention is required. This medication may cause inflammation or irritation at the injection site when administered intravenously, so caution is needed, especially when using injectable forms. If persistent diarrhea or abdominal pain occurs during antibiotic use, serious gastrointestinal conditions such as pseudomembranous colitis may occur, and immediate consultation with healthcare professionals is necessary. If long-term use of this medication is required, it should be administered under regular clinical supervision and limited to the shortest duration possible.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor → severe allergic reaction. Severe rash with high fever, blisters, skin peeling, and pain in oral/ocular mucosa → severe skin adverse reactions. Shortness of breath or difficulty in breathing, asthma attacks, breathing irregularities accompanied by cough and fever → respiratory problems. Yellowing of the skin or eyes (jaundice), extreme lethargy → liver dysfunction (jaundice). Sudden onset.

Mild side effects

Occasionally, symptoms related to the hematologic system such as granulocytopenia, hemolytic anemia, pancytopenia, thrombocytopenia, leukopenia, fever, sore throat, oral ulcers, paleness of skin and mucous membranes, conjunctival pallor, and purpura. Skin symptoms may include rash, itching, candidiasis, conjunctival and scleral injection, erythema, urticaria, photodermatitis, systemic lupus erythematosus (SLE), and purpura. Liver function tests may show elevated AST/ALT, ALP, γ-GTP, hepatitis, liver necrosis, and serum bilirubin changes.

This medication is sensitive to light and should be stored in a tightly sealed container that does not allow light. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

White or nearly white round tablets

Package unit

500 tablets/bottle