Aju Digoxin Injection

Adult dosage

(Oral: tablets, elixir) Rapid digitalization (digitalizing dose: 1.0-4.0㎎): Administer an initial dose of 0.5-1.0㎎ of digoxin, followed by 0.5㎎ orally every 6-8 hours, continuing until an adequate effect is achieved. Slow digitalization may also be used. Maintenance therapy: Administer 0.25-0.5㎎ orally per day. (Injection) Rapid digitalization (digitalizing dose: 1.0-2.0㎎): Inject 0.25-0.5㎎ of digoxin intravenously per dose every 2-4 hours, continuing until an adequate effect is achieved. Slow digitalization may also be used. Maintenance therapy: Inject 0.25㎎ intravenously per day.

Children's dosage

(Oral: tablets, elixir) Under 2 years: Administer 0.06-0.08㎎/㎏ of body weight per day in 3-4 divided doses. 2 years and older: Administer 0.04-0.06㎎/㎏ of body weight per day in 3-4 divided doses. Maintenance therapy: Administer 1/5-1/3 of the digitalizing dose. Adjust the dose as appropriate according to age and symptoms. (Injection) Neonates and premature infants: Inject 0.03-0.05㎎/㎏ of body weight per day intravenously or intramuscularly in 3-4 divided doses. Under 2 years: Inject 0.04-0.06㎎/㎏ of body weight per day intravenously or intramuscularly in 3-4 divided doses. 2 years and older: Inject 0.02-0.04㎎/㎏ of body weight per day intravenously or intramuscularly in 3-4 divided doses. Maintenance therapy: Inject 1/15-1/10 of the digitalizing dose intravenously or intramuscularly. Adjust the dose as appropriate according to age and symptoms.

As this medication is an ampule injection, great care must be taken when cutting the glass container to prevent glass fragments from mixing in. Special caution is required when used in children or the elderly. This medication should not be administered to certain heart disease patients. For example, patients with atrioventricular block, sinoatrial block, carotid sinus syndrome, digitalis toxicity, obstructive cardiomyopathy, and others should not use this medication. Patients with ventricular tachycardia or Wolff-Parkinson-White syndrome should also not be given this medication. Additionally, patients who have allergic reactions to this drug must also refrain from using it. This medication should be used cautiously in some patients. Patients with acute myocardial infarction, ventricular ectopy, endocarditis, cor pulmonale, thyroid dysfunction, or kidney impairment may experience toxicity even at low doses, so caution is necessary. Patients undergoing dialysis or those with electrolyte imbalances also need to be monitored carefully when taking this drug. Patients with dysautonomia or severe respiratory illnesses may also be sensitive to this medication, so close observation is required. Side effects of this drug may include gastrointestinal symptoms, arrhythmia, visual disturbances, dizziness, and fatigue. If these symptoms occur, it may be necessary to reduce the dose or temporarily stop administration and then restart at a lower dose. Additionally, if hypersensitivity reactions such as rash, urticaria, or edema occur, administration should be immediately discontinued. Occasionally, symptoms such as gynecomastia or muscle weakness may appear rarely. When using this medication, it is essential to confirm whether similar cardiac glycoside medications have been taken within the past 2-3 weeks and to determine the dose carefully. Patients with gastrointestinal issues may require a higher dose. Interactions may occur when used with other medications, especially with potassium-wasting diuretics, amiodarone, spironolactone, calcium agents, and beta-blockers, so close monitoring is required when these are used in combination. Certain drugs may also interfere with the absorption of this medication, so adjusting the administration intervals is vital. Women who are pregnant or may become pregnant should carefully weigh the benefits and risks when using this medication. This medication can also be passed into breast milk, so nursing women should use it cautiously. In pediatric and geriatric populations, the risk of side effects is higher, so careful monitoring and dose adjustments are essential when administering this drug. When used as an injection, rapid intravenous injection can cause vasoconstriction and hypertension, so it is crucial to slow the injection rate for patients with hypertensive heart failure or acute myocardial infarction.

• loss of appetite
• nausea
• vomiting
• diarrhea
• arrhythmias
• atrioventricular block
• tachycardia
• significant bradycardia
• visual disturbances
• dizziness

This medication should be stored in a sealed container to prevent exposure to air or moisture. Doing so will help maintain the medication's efficacy and prevent deterioration.

Appearance

A colorless, transparent ampule filled with a slightly viscous colorless liquid.

Package unit

1 mL/ampule x 10