Yuhan Jit Tablets 100mg (Isoniazid) (Military Supply Name: Isoniazid tablet K.P. 100mg)

Adult dose

1. For treatment Adults: Administer 200∼400 mg (4∼8 mg/kg) of isoniazid orally once daily; if necessary, administer in divided doses. For intermittent administration twice a week, administer 600∼800 mg per dose. As a rule, administer in combination with other antitubercular agents. Adjust the dose as appropriate according to age and symptoms. 2. For prevention Adults: Administer 300 mg of this medicine once daily; if necessary, administer in divided doses.

Child dose

1. For treatment Children: Administer 10∼15 mg/kg of body weight per day of this medicine (maximum 300 mg per day) once daily; if necessary, administer in divided doses. 2. For prevention Children: Administer 10 mg/kg of body weight per day of this medicine (maximum 300 mg per day) once daily; if necessary, administer in divided doses.

This medication should not be used in specific patients. Patients who are allergic to this drug or any of its components, those with severe liver dysfunction, and those who have previously experienced serious side effects from this drug must not take it. Patients with liver dysfunction or a history of liver issues, patients with reduced kidney function, patients with a history of mental illness, patients with alcohol dependence, patients with seizure disorders, patients with blood disorders or a tendency to bleed, patients with drug allergies, pregnant women or those who may become pregnant, nursing mothers, and patients taking specific medications must use this drug with caution. This drug can cause hypersensitivity reactions such as fever, rash, lymphadenopathy, and vasculitis; if any of these symptoms occur, administration must be stopped immediately. Severe rashes or dermatitis, and symptoms like systemic lupus erythematosus may rarely occur, so careful monitoring is needed. Liver function abnormalities may arise, thus regular liver function tests are necessary, and if symptoms of hepatitis or jaundice occur, drug use must be discontinued immediately. Blood test results can show abnormalities, and caution is required for signs of bleeding tendency, anemia, or leukopenia. Neuropsychiatric side effects such as confusion, hallucinations, depression, seizures, headaches, dizziness, or peripheral nerve symptoms may rarely occur. In such cases, the dose should be reduced or the drug halted, and vitamin B6 (pyridoxine) may need to be administered as necessary. Optic neuritis or optic nerve atrophy may rarely occur; if vision changes are noticed, consult a doctor immediately. Gastrointestinal symptoms such as loss of appetite, nausea, vomiting, or abdominal pain can occur. This drug may induce endocrine disorders such as gynecomastia, menstrual irregularities, erectile dysfunction, and hyperglycemia, so symptoms should be reported. Central nervous system dysfunction may also occur rarely, necessitating careful monitoring for neurological symptoms. During administration of this drug, symptoms like interstitial pneumonia, kidney impairment, arthralgia, myalgia, dysuria, and dry mouth may manifest, so report any unusual signs to healthcare personnel immediately. This drug can affect liver function, so regular testing should be performed to check liver status, and if abnormalities are found, administration should be stopped immediately. Due to numerous potential interactions with other medications, particularly antitubercular agents, anticoagulants, antiepileptics, antihypertensive drugs, antidepressants, antidiabetic agents, disulfiram, rifampin, carbamazepine, caution is needed when taken together. Interactions with specific foods may also occur, so caution is advised with cheese or certain fish consumption. Pregnant or breastfeeding women should avoid taking this drug, and it is advisable to refrain from drug use while nursing. Elderly individuals may have diminished body function, increasing the likelihood of side effects, necessitating careful observation during administration. In cases of overdose, symptoms such as nausea, vomiting, dizziness, hallucinations, seizures, and coma may occur, requiring immediate medical attention for appropriate treatment. Long-term use of this drug may increase the risk of pulmonary tumor development, although the correlation in humans is unclear, so it should be used according to a doctor's guidance.

Fever, rash, lymphadenopathy, vasculitis, mucocutaneous syndrome, toxic epidermal necrolysis, DRESS syndrome, acute generalized exanthematous pustulosis, exfoliative dermatitis, systemic lupus erythematosus, hepatitis, severe liver dysfunction, jaundice, elevated AST/ALT, elevated bilirubin, agranulocytosis, thrombocytopenia, hemoptysis, hematemesis, epistaxis, retinal hemorrhage, anemia, erythrocytosis, leukopenia, eosinophilia, memory impairment, hallucinations, mood swings, agitation, delirium, depression, encephalopathy, seizures, headache, dizziness, fatigue, muscle cramps, peripheral sensory disturbance, loss of orientation, optic neuritis, optic atrophy, malaise, pancreatitis, loss of appetite, nausea, vomiting, abdominal distension, abdominal pain, constipation, gynecomastia, galactorrhea, menstrual disorders, erectile dysfunction, pyridoxine deficiency, pellagra, hyperglycemia, metabolic acidosis, ataxia, movement disorders, speech disorders, ocular movement disorders, swallowing difficulties, interstitial pneumonia, renal failure, interstitial nephritis, nephrotic syndrome, arthralgia, myalgia, dysuria, dry mouth, hyperreflexia, nausea, dizziness, visual disturbances, hallucinations, coma, metabolic acidosis, hyperglycemia

This medication is sensitive to light, so it should be stored in a dark container that does not allow light to enter. It should also be stored in a tightly sealed container to maintain its effectiveness by preventing exposure to air.

Appearance

White round tablets

Package unit

1000 tablets/bottle