Korea Dextrose Injection (10%)

Adult administration

Administer 20 to 500 mL via intravenous injection. The rate of intravenous infusion should not exceed 0.5 g/kg per hour as glucose. Use an appropriate amount for solution dilution of the injection. Adjust according to age and symptoms.

This medication may allow glass fragments to mix when the ampule is opened, so special care must be taken to prevent glass fragments from entering, especially when using it on children or the elderly. The glucose contained in this medication can increase the consumption of vitamin B1 (thiamine) in the body during intravenous administration, which can lead to severe deficiency, so caution is required. This medication should not be administered to patients with specific conditions such as storage dehydration, excessive water retention, hyperglycemia, acidosis, hypokalemia, hyperosmolar coma, diabetes insipidus, anuria, or hepatic coma. The hypertonic liquid form of this medication should also not be used in patients with intraspinal hemorrhage, intracranial hemorrhage, or delirium tremens. Patients with tendencies for potassium, phosphate, or magnesium deficiency, or conditions such as hyponatremia, diabetes insipidus, renal failure, heart failure, severe malnutrition, thiamine deficiency, sepsis, severe trauma, etc., should use this medication with caution. This medication may cause electrolyte imbalance or fluid overload if administered in large doses or rapidly, so it should be given slowly, and exceeding the recommended dosage may raise blood bilirubin and lactate levels. After administration, side effects such as hypokalemia, hyperosmolar coma, acidosis, dehydration, hyperosmolarity, polyuria, phlebitis, thrombosis, and pain at the injection site may occur, so caution is advised. Long-term use may affect insulin secretion, and if necessary, insulin should be administered together; patients after surgery or with diabetes mellitus should strictly control blood sugar levels. During pregnancy, the safety for the fetus has not been established, so it should only be used if the benefits of treatment outweigh the risks, and care should be taken when administering during labor due to the risk of hyperglycemia and metabolic acidosis for both the mother and newborn. Newborns, especially preterm and low birth weight infants, are at higher risk of hypoglycemia or hyperglycemia and should have their blood sugar levels closely monitored, and elderly patients may require more cautious administration due to decreased physical functions. Overdosage may lead to hyperglycemia or diabetes, necessitating insulin treatment in such cases. Subcutaneous injections should be avoided as they may cause electrolyte imbalance and local irritation, and any remaining solution should be discarded after opening. To reduce the risk of infection during administration, cleanliness should be maintained during the injection process and the medication should be warmed to body temperature before use. Due to the risk of thrombophlebitis, special care should be taken when administering hypertonic solutions, and abrupt discontinuation after high-concentration solutions may induce hypoglycemia. It should not be administered simultaneously with blood, and when mixed with other medications, careful verification of chemical and physical compatibility should be performed before administration.

Mild side effects

Hypokalemia, hyperosmolar coma, acidosis, dehydration, hyperosmolarity, polyuria accompanied by glucose detection, fluid or solute overload, fluid-electrolyte imbalance, congestion, pulmonary edema, hyperglycemia, nephron loss, fever, phlebitis, thrombosis, blood leakage, pain at the injection site, uremia

This medication should be stored in a sealed container to prevent exposure to air and should be kept at a temperature between 1 degree and 30 degrees Celsius at room temperature. By storing it this way, the medication's effectiveness can be well maintained, preventing deterioration.

Appearance

A colorless, transparent liquid with a sweet taste, filled into a colorless, transparent container made of glass, polypropylene, or multilayer film plastic.

Package unit

500mL/bottle, 1000mL/bottle, 500mL/bag, 1000mL/bag