Chungwoo 20% Dextrose Injection

Adult administration

Administer intravenously 20-500mL per dose. The rate of drip intravenous injection should be less than 0.5g/kg per hour of glucose. Use an appropriate amount to dissolve and dilute the injection. Adjust the dosage according to age and symptoms.

This medication may contain glass fragments when using ampule injections, so the container should be carefully cut, particularly when administered to children or the elderly. Patients receiving this medication through intravenous injection containing glucose should be cautious as vitamin B1 can be rapidly depleted, potentially leading to severe deficiency symptoms. This medication should not be used in patients with specific conditions such as storage dehydration, excessive fluid state, hyperglycemia, acidosis, hypokalemia, hyperosmolar coma, glucose intolerance, anuria, and hepatic coma. In patients with spinal or intracranial hemorrhage, do not administer this medication in hypertonic solution form, and caution is needed in severely dehydrated patients as it may worsen hyperosmolar conditions. Use this medication carefully in patients showing tendencies towards potassium, phosphate, magnesium deficiencies or in cases of hyponatremia, diabetes insipidus, renal failure, heart failure, and severe cases; special attention is also required for patients receiving specific steroid medications and diabetic patients. Administration in large amounts or rapidly may lead to electrolyte imbalances, fluid overload, pulmonary edema, etc., so the rate and dose of administration must be adjusted. Moreover, excessive administration of this medication may lead to increased levels of bilirubin and lactate, as well as adverse reactions such as hypokalemia, hyperosmolar coma, acidosis, and polyuria. Long-term administration may influence insulin secretion, so insulin should be administered when necessary, and blood glucose and electrolyte concentrations should be monitored regularly. The safety of this medication during pregnancy has not been fully established, and it should be used cautiously considering potential risks to the fetus, especially during administration at delivery regarding blood glucose control of the mother and newborn. When administering to children or newborns, their fluid and electrolyte regulation abilities may be immature, thus careful observation of blood glucose and electrolyte concentrations is necessary, particularly as low birth weight infants may have an increased risk of intracranial hemorrhage. In the elderly, cautious administration of this medication is necessary due to diminished body functions. In cases of overdose, symptoms of hyperglycemia or diabetes may appear, therefore insulin treatment should be implemented if necessary. Subcutaneous administration is not recommended due to the severe circulatory failure and local irritation caused by electrolyte movement in the plasma. After opening, it should be used immediately, and any remaining medication should be discarded, as there is a risk of infection, particularly during intravenous administration. This medication should be warmed to body temperature before use, and caution is necessary during hypertonic solution administration due to the risk of thrombophlebitis. Abrupt cessation of administration can lead to hypoglycemia, thus it should be gradually adjusted, and care should be taken when administered simultaneously with blood as agglutination reactions may occur. When mixing with other medications, it is important to be fully aware of potential chemical and physical adverse reactions, and careful observation is necessary, using the mixture immediately after it is prepared. To reduce the risk of air embolism due to air in the container, continuous connection administration should be avoided.

Mild side effects

• Hypokalemia
• hyperosmolar coma
• acidosis
• dehydration
• hyperosmolarity
• polyuria
• fluid or solute overload
• fluid-electrolyte imbalance
• congestion
• pulmonary edema

This medication should be stored in a sealed container to prevent air or moisture penetration. This way, the effectiveness of the medication can be maintained for a long time and degradation can be prevented.

Appearance

A colorless and transparent liquid in a multi-layer film plastic container.

Package unit

20mL×50, 600mL