Empagliflozin/Metformin Extended-Release Tablet 12.5/750 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The dosage of this medication is based on a maximum of 25 mg of Empagliflozin and 2000 mg of extended-release Metformin Hydrochloride per day, taking into consideration the patient's treatment regimen, effectiveness, and tolerance. This medication is to be taken once daily at dinner to minimize gastrointestinal side effects associated with Metformin. The extended-release 10/1000 mg or 25/1000 mg formulations are to be taken once daily for 1 tablet.

This medication consists of two components, Metformin and Empagliflozin, and is primarily used in the treatment of type 2 diabetes. While taking this medication, there is a rare possibility of serious lactic acidosis occurring, so caution is particularly necessary for patients with impaired kidney function or those with heart or liver disease. When used with other diabetes medications, hypoglycemic symptoms may occur, so blood sugar levels should be closely monitored. This medication should not be used in patients with moderate to severe impairment of kidney function, acute kidney injury, dehydration, severe infection, or heart failure. It should be temporarily discontinued before any examination involving iodine contrast agents, and administration should be resumed only after confirming that kidney function has returned to normal post-examination. Pregnant women or women who may become pregnant, as well as nursing mothers, should avoid using this medication. This medication may increase the risk of genital and urinary tract infections, so immediate consultation with healthcare professionals is required if any signs of infection appear. From the time of use, if symptoms such as hypoglycemia, abdominal pain, muscle pain, difficulty breathing, weakness, or other adverse effects occur, the patient should inform a physician immediately. Elderly patients or those with compromised kidney function should regularly have their kidney function evaluated, and dose adjustments should be made if necessary. It is advisable to avoid alcohol consumption while using this medication, and this medication may be temporarily paused in case of dehydration, diarrhea, or vomiting. This medication should be swallowed whole and should not be chewed or broken, although the tablet shell may be excreted in the stool, which is normal. If there are other medications being used concurrently, there may be potential for drug interactions, so all medications being taken should be disclosed to healthcare personnel. In the case of overdose, serious side effects such as lactic acidosis may occur, necessitating immediate treatment at a hospital.

Serious side effects

• Urticaria
• angioedema
• perineal necrosis
• ketoacidosis
• lactic acidosis
• pyelonephritis
• urinary sepsis
• acute kidney injury
• myocardial infarction
• cerebral infarction

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to protect from air and moisture, at a cool room temperature between 1 and 30 degrees Celsius.

Appearance

Pink oval extended-release film-coated tablet

Package unit

30 tablets/bottle