Polmin Empagliflozin and Metformin Extended Release Tablets 25/1000 mg

Adult dose

This medication is taken once daily with the evening meal. The dosage should not exceed a maximum of 25 mg of empagliflozin and 2000 mg of extended-release metformin hydrochloride, and it should be determined based on each patient's current treatment, effectiveness, and tolerability. For the extended-release forms of this medication, 10/1000 mg or 25/1000 mg, one tablet should be taken once daily. For the 5/1000 mg or 12.5/1000 mg extended-release tablets, one should take two tablets simultaneously once daily.

This medication is used in the treatment of diabetes and helps in controlling blood sugar levels. Caution is needed as there is a risk of a rare side effect known as severe lactic acidosis while taking this medication. Lactic acidosis can result in dangerous conditions due to excessive accumulation of lactic acid in the body, posing a risk to life. Furthermore, one should be wary of hypoglycemia when taking this medication in conjunction with other drugs that lower blood sugar, such as insulin or sulfonylureas. This medication should not be administered to patients with impaired kidney function or certain heart diseases, acute infections, or severe liver dysfunction. Before undergoing tests or surgery, this medication should be temporarily discontinued and can be resumed once kidney function returns to normal. During the use of this medication, if symptoms of dehydration, diarrhea, or vomiting occur, one must consult a physician immediately, especially for elderly patients or those at risk of reduced fluid volume. This medication can cause genital infections or urinary tract infections, and prompt treatment should be sought if related symptoms appear. Moreover, levels of vitamin B12 may decrease, so regular blood tests are recommended for long-term use. It is safest for women who are pregnant or may become pregnant to avoid this medication, as well as nursing mothers to refrain from taking it. This medication has not been confirmed for safety and efficacy in children, thus is not recommended for patients under 18. In cases of overdose, severe side effects such as hypoglycemia or lactic acidosis may occur, so adherence to the prescribed dosage is vital; if any unusual symptoms arise, seek immediate medical care. It is advisable to avoid alcohol consumption during the course of this medication, and potential drug interactions must be discussed with a physician or pharmacist before concurrent use with other medications. Lastly, this medication should be swallowed whole, without breaking, crushing, or chewing the tablets; it is normal for the tablet coating to appear in the stool.

Serious side effects

Hives, angioedema, perineal necrosis, lactic acidosis, ketoacidosis, urinary sepsis, pyelonephritis, abnormal liver function tests, hepatitis, liver abnormalities (jaundice), cerebral infarction, myocardial infarction, acute pyelonephritis, acute kidney injury, worsening of heart failure, sepsis, shock, hypoglycemia (severe, requiring treatment), respiratory distress, asthma attacks, difficulty breathing, chest tightness, severe edema accompanied by elevated blood pressure, severe hypertension with significant edema

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• altered taste
• itching
• rash
• erythema

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. Additionally, it is advised to keep it at room temperature, neither too hot nor too cold, ideally between 1 to 30 degrees Celsius.

Appearance

Light yellow, double convex, oval-shaped extended-release film-coated tablets

Package unit

30 tablets/bottle