Trinam 2.5/500 mg (Linafagliptin, Metformin)

Adult dose

The dose of this medication is determined within the range of Linafagliptin 2.5 mg (Linafagliptin besilate 3.34 mg) and Metformin 1000 mg not exceeding two times a day. Take 1 tablet twice daily with meals. 1. If not previously treated with Metformin: The initial dose is this medication 2.5/500 mg once daily, 1 tablet at a time, increasing to a maximum of this medication 2.5/1000 mg twice daily, 1 tablet at a time.

This medication consists of two main ingredients and helps in controlling blood sugar. However, this medication may cause serious side effects, such as lactic acidosis, so it should not be administered to patients with poor kidney function or certain heart or liver disorders. It is also advisable for pregnant or breastfeeding women and patients with very poor nutritional status or acute illnesses not to use this medication. Before starting this medication, kidney function must be tested and regularly monitored during treatment. There is a risk of hypoglycemia, so caution is required when used with other hypoglycemic agents or insulin, and dose adjustments may be necessary as needed. If symptoms such as persistent abdominal pain, muscle weakness, difficulty breathing, or coma occur, it is essential to inform healthcare professionals immediately. Additionally, rare side effects such as acute pancreatitis or blistering dermatitis similar to epidermolysis bullosa may occur; thus, if any suspicious symptoms arise during the medication, it should be discontinued immediately and consult with a specialist. This medication may lower vitamin B12 levels, so it is advisable to regularly monitor vitamin B12 levels with long-term use. There may be interactions when taken with certain other medications, so any other medications the patient is taking should be reported to a doctor or pharmacist. This medication is not recommended for children and adolescents as its safety and efficacy have not been sufficiently established. Elderly patients should use this medication with caution, as decreased kidney function is common, and regular kidney function tests are necessary. Lastly, this medication should be avoided during pregnancy and is not recommended during breastfeeding. There is insufficient research regarding the effects of this medication on driving or operating machinery, so caution is advised.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, blistering dermatitis similar to epidermolysis bullosa, liver dysfunction (abnormal liver function tests, hepatitis), angina pectoris, acute myocardial infarction, unstable angina, congestive heart failure, cardiac arrest, pneumonia, difficulty breathing, asthma, severe allergic reactions (urticaria, angioedema), severe skin reactions (severe rash, blisters, skin peeling), severe edema (facial swelling), severe and disabling arthralgia

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• hypoglycemia
• taste disturbances
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius, as this helps preserve the medication's effectiveness.

Appearance

Yellow, oval, biconvex film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/bottle