Rinatop Duo Sustained Release Tablet 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication should be taken once daily with the evening meal. The dose of metformin hydrochloride should be gradually increased. For sustained release properties, this medication should be swallowed whole without breaking, crushing, grinding, or chewing. Take one tablet of this medication 5/1000 mg sustained release once daily. Patients taking the 2.5/1000 mg sustained release tablet should take two tablets once daily.

This medication contains two ingredients, metformin hydrochloride and linagliptin. Firstly, this medication can rarely cause a serious condition called lactic acidosis, which can lead to dangerous levels of lactic acid in the body and should be approached with caution. This medication should not be used in certain patients, such as those who are allergic to this medication, those with type 1 diabetes, severely impaired kidney function, severe liver dysfunction, acute alcohol intoxication, and severe heart diseases should avoid its use. Additionally, since this medication can cause hypoglycemia, it is necessary to monitor blood sugar closely when taken with insulin or sulfonylureas, and reduce the doses of those medications if necessary. Patients with impaired kidney function should have their kidney function regularly checked before and after taking this medication, and it should not be used if kidney function is very poor. If an iodinated contrast agent is administered during radiological tests, kidney damage can occur, necessitating the discontinuation of this medication for a certain period before and after the test, resuming only after kidney function has recovered. Patients scheduled for surgery should stop taking this medication 48 hours before the surgery and resume only after kidney function and condition have stabilized post-surgery. Women who are pregnant or planning to become pregnant are advised to avoid taking this medication, and it should not be used during breastfeeding. This medication should be swallowed whole and not broken or chewed, and while the tablet coating may appear in feces, this is normal. If there are sudden severe abdominal pains, vomiting, or skin blisters or rashes during the course of treatment, consult a physician immediately, and the medication should be discontinued if such symptoms occur. This medication can reduce vitamin B12 levels, so those on long-term treatment should have their vitamin B12 levels checked and supplemented if necessary. This medication can interact with other drugs, so if there are other medications being taken simultaneously, it is vital to inform a doctor or pharmacist, especially with those that can affect kidney function. Elderly patients often experience decreased kidney function, so kidney function should be frequently monitored while taking this medication, and doses adjusted if needed. In case of overdose, there is a risk of lactic acidosis and immediate medical treatment is required, with blood dialysis generally being the most effective treatment method.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function (liver dysfunction, hepatitis), severe allergic reactions, severe and debilitating arthralgia, angioedema, severe rash accompanied by high fever, blistering, skin peeling, pain in oral/ocular mucous membranes, difficulty in breathing, asthma, shortness of breath, feeling of suffocation, jaundice, abdominal pain, severe myasthenia, severe edema, increased blood pressure, severe allergic reactions, acute renal failure

Mild side effects

• Altered taste
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcers
• abnormal liver function tests

This medication should be stored in a tightly closed container to protect it from air and moisture, at a safe temperature between 1 degree Celsius and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness and prevents degradation.

Appearance

Yellow oval sustained release film-coated tablets

Package unit

30 tablets per bottle