Empagliflozin 12.5/1000mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage for this medication is 1 tablet per dose, taken 2 times a day. Dosage is determined within the range that does not exceed 25 mg of empagliflozin and 2000 mg of metformin. When used in combination with metformin alone or with insulin, the recommended dosage is to take 5 mg of empagliflozin twice daily, and in cases where additional blood glucose control is needed, the dose can be increased to 25 mg of empagliflozin. This medication is designed to minimize gastrointestinal side effects related to metformin.

This medicine may cause a rare but serious side effect called lactic acidosis. It should be avoided particularly in patients with poor kidney function, dehydration, severe infections, or heart issues. Additionally, there is an increased risk of hypoglycemia when used with other antidiabetic medications that lower blood sugar, such as insulin or sulfonylureas, so caution is needed. It should not be administered to patients with allergies to ingredients in this medication, severe kidney impairment, type 1 diabetes, acute or chronic metabolic acidosis, acute heart failure, or those undergoing tests using contrast agents. While on treatment, it is essential to regularly monitor kidney function, especially in elderly patients or those with diminished kidney function. In situations where there is a risk of fluid loss, temporarily discontinuing this medication may be necessary, and caution should also be taken in cases of gastrointestinal disorders, liver dysfunction, excessive alcohol consumption, or malnutrition. This medication may increase the risk of urinary tract infections and genital infections, so patients should consult their doctor immediately if symptoms of infection occur. It is advisable for women who are pregnant or may become pregnant and nursing mothers to avoid using this medication, and it is not recommended for children since safety and effectiveness have not been established. In case of overdose, hemodialysis may be required, so patients must adhere to the prescribed dosage when taking the medication. Regular blood tests and monitoring of physical condition are vital while taking this medication, and patients should inform their healthcare provider immediately if any unusual symptoms occur.

Serious side effects

• Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reactions.
• Severe rash with high fever accompanied by blisters, skin peeling, oral/ocular mucosal pain → severe skin adverse reactions.
• Shortness of breath or difficulty breathing, asthma attack, combined cough + fever respiratory issues → respiratory problems.
• Jaundice or yellowing of the skin or eyes, severe lethargy → liver issues (jaundice).
• Sudden symptoms.

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air and moisture, so it must be stored in a tightly closed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature to maintain its efficacy and safety over time.

Appearance

Biconvex oval film-coated tablets with a dark brownish purple color.

Package unit

60 tablets/box [10 tablets/PTP x 6], 10 tablets/box [10 tablets/PTP x 1], 60 tablets/bottle, 30 tablets/bottle