Projea Prefilled Injection (Ramosetron Hydrochloride)

Adult dosage

Administer 0.3 mg of Ramosetron Hydrochloride intravenously once daily. If the effect is insufficient, the same dose may be administered additionally. However, do not exceed 0.6 mg in total per day. Adjust the dosage based on symptoms.

This medication should not be used by individuals who are allergic to this drug or any of its components. Caution should be exercised when administering this medication to patients taking other serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Serious allergic reactions, such as shock or anaphylaxis-like symptoms, may occur when using this medication; if symptoms occur, administration should be immediately stopped and appropriate treatment should be received. Additionally, seizures similar to epilepsy have been reported; hence, patients at risk of seizures should use caution. Various side effects such as headache, diarrhea, liver dysfunction, itching, and rash may occur, so consult with healthcare personnel if symptoms arise. This medication is primarily used in patients undergoing chemotherapy treatment that causes strong nausea and vomiting. When used together with other serotonergic drugs, there is a risk of serious side effects known as serotonin syndrome; therefore, patient conditions should be closely monitored in such cases. Caution should be exercised when taken with medications that affect the enzymes that break down this drug in the liver, as this can result in increased blood concentration of the medication and a heightened risk of side effects. Women who are pregnant or may become pregnant should carefully consider the risks and benefits of using this medication, as its safety has not been established. It is recommended that breastfeeding women discontinue breastfeeding as this medication may be excreted in breast milk. Safety in pediatric patients has not been sufficiently confirmed; therefore, use in children should be approached with caution. Elderly patients may have diminished body function, so they should be monitored closely for adverse reactions. Care should be taken when mixing with certain injection solutions, as problems may arise; in most cases, it is safest to avoid mixing.

Serious side effects

Shock, anaphylaxis-like symptoms (chest discomfort, difficulty breathing, asthma), seizure-like episodes

Mild side effects

Headache, feeling of heaviness in the head, rash, itching, redness, diarrhea, constipation, increased BUN, elevated serum creatinine, liver dysfunction (increased AST, ALT, r-GTP, bilirubin), feeling of warmth, hiccups, warmth sensation in the head, tingling of the tongue, insomnia, rash

Store this medication away from light and in a sealed container to prevent air ingress. Additionally, it is recommended to store at room temperature between 1 and 30 degrees Celsius.

Appearance

A colorless and transparent liquid in a single-use prefilled syringe.

Package unit

Box - 5 prefilled syringes/box [2 milliliters/prefilled syringe], Box - 6 prefilled syringes/box [2 milliliters/prefilled syringe]