Duojoin Tablet

Adult dose

Adults: Take 1 tablet twice daily. This medicine may be taken with or without food. Take this medicine whole; do not crush or split it. ○ Patients with hepatic impairment This medicine is not recommended for initial treatment in patients with hepatic impairment who require a dose reduction (see Precautions for Use, 5. General Precautions)

This medication may cause gastrointestinal bleeding in those who regularly consume 3 or more alcoholic beverages daily, so it must be discussed with a doctor or pharmacist. The medication can increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, so special caution is needed for individuals with a history of cardiovascular disease or risk factors. It should be used at the lowest possible dose for the shortest duration. Serious adverse reactions such as gastrointestinal perforation, ulcers, and bleeding may occur, so elderly individuals or those with a history of gastrointestinal disease should carefully monitor for any symptoms during use. Patients with allergies or hypersensitivity to this medication, severe cardiovascular disease, liver disease, renal impairment, active peptic ulcers, or inflammatory bowel disease, as well as pregnant or nursing women, should not take this medication. Patients with weakened liver or kidney function, asthma, hypertension, heart failure, edema, and elderly individuals should use caution when taking this medication and may require regular testing per a doctor's instructions. While taking this medication, adverse reactions such as dyspepsia, abdominal pain, headache, skin rashes, edema, dizziness, and insomnia may occur, so if any symptoms arise, immediate consultation with healthcare personnel is necessary. Women who are pregnant or may become pregnant should not take this medication, and those who plan to conceive should consult a doctor before taking it. This medication is metabolized in the liver, so caution is necessary when taken with other medications that may impact liver function, and potential interactions with certain drugs should be communicated. Combining this medication with antihypertensive agents, diuretics, anticoagulants, antidepressants, and immunosuppressants may increase the risk of renal function decline or bleeding, so it should be taken under a doctor's guidance. During the use of this medication, regular blood tests, liver function tests, and kidney function tests should be conducted to check for abnormalities, and if any anomalies are found, the medication should be stopped immediately and healthcare personnel should be consulted. Dizziness or drowsiness may occur when taking this medication, so it is advisable to avoid activities that require alertness, such as driving or operating machinery. The safety and efficacy of this medication have not been established for children and adolescents, so it is recommended not to use it in these populations. Elderly individuals may have a higher risk of decreased kidney and liver function and should be closely monitored when taking this medication, starting at the minimum dose for individuals with low body weight. In case of overdose, symptoms such as vomiting, lethargy, drowsiness, nausea, and abdominal pain may occur and immediate medical attention may be needed. This medication should be kept out of reach of children and should not be transferred to other containers as this could adversely affect its quality.

Gastrointestinal bleeding, cardiovascular thrombotic reaction, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, dyspepsia, nausea, upper abdominal pain, constipation, diarrhea, dry mouth, esophageal pain, stomatitis, COVID-19, acute pyelonephritis, facial swelling, pain at the implantation site, peripheral edema, fever, pruritus, psoriasis, rash, skin engorgement, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated blood pressure, increased serum uric acid, elevated gamma-glutamyl transferase, arthralgia, lumbago, coccygodynia, flank pain, headache, carpal tunnel syndrome, lymphadenopathy, cholelithiasis, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle hypertonia, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, distension, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, itching, urticaria, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, hepatic dysfunction, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, anorexia, elevated LDH, hypoglycemia, hyponatremia, bursa, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pustulosis, contact dermatitis, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, visual confusion, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorder, chest pain, headache, dizziness, constipation, gastric ulcer, urticaria, anemia, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, chest pain, hyperlipidemia, diabetes, weight gain, fractures, arthralgia, positive RA factor, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing impairment, anaphylactic reaction, hallucinations, intracranial hemorrhage, aseptic meningitis, taste loss, smell loss, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, hepatic failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruption, acute generalized pustular rash, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, female infertility, chest pain, heartburn, dry mouth, nausea, diarrhea, weakness, hypertriglyceridemia, hypercholesterolemia, transaminitis, increased ALT, increased AST, itching, leukopenia, neutropenia, chest discomfort, blurred vision, dizziness, drowsiness, rash, alopecia, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, papular rash, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug eruption associated with eosinophilia and systemic symptoms, urticaria, gastritis, gastrointestinal pain, gastroesophageal reflux disease, epigastric discomfort, epigastric pain unrelated to food, insomnia, anorexia, anxiety, increased appetite, depression, neurogenic hypersensitivity, drowsiness, fatal intracranial hemorrhage, confusion, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, sinusitis, pharyngitis, rhinitis, bronchitis, bronchospasm, exacerbated bronchospasm, cough, dyspnea, laryngitis, pneumonia, epistaxis, dysphonia, vesicular dermatitis, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, tinnitus, hearing impairment, hepatic dysfunction, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, anorexia, elevated LDH, hypoglycemia, hyponatremia, bursa, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pustulosis, contact dermatitis, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, visual confusion, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorder, chest pain, headache, dizziness, constipation, gastric ulcer, urticaria, anemia, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, chest pain, hyperlipidemia, diabetes, weight gain, fractures, arthralgia, positive RA factor, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing impairment, anaphylactic reaction, hallucinations, intracranial hemorrhage, aseptic meningitis, taste loss, smell loss, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, hepatic failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruption, acute generalized pustular rash, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, female infertility, chest pain, heartburn, dry mouth, nausea, diarrhea, weakness, hypertriglyceridemia, hypercholesterolemia, transaminitis, increased ALT, increased AST, itching, leukopenia, neutropenia, chest discomfort, blurred vision, dizziness, drowsiness, rash, alopecia, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, papular rash, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug eruption associated with eosinophilia and systemic symptoms, urticaria, gastritis, gastrointestinal pain, gastroesophageal reflux disease, epigastric discomfort, epigastric pain unrelated to food, insomnia, anorexia, anxiety, increased appetite, depression, neurogenic hypersensitivity, drowsiness, fatal intracranial hemorrhage, confusion, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, sinusitis, pharyngitis, rhinitis, bronchitis, bronchospasm, exacerbated bronchospasm, cough, dyspnea, laryngitis, pneumonia, epistaxis, dysphonia, vesicular dermatitis, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, tinnitus, hearing impairment, hepatic dysfunction, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, anorexia, elevated LDH, hypoglycemia, hyponatremia, bursa, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pustulosis, contact dermatitis, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, visual confusion, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorder, chest pain, headache, dizziness, constipation, gastric ulcer, urticaria, anemia, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, chest pain, hyperlipidemia, diabetes, weight gain, fractures, arthralgia, positive RA factor, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing impairment, anaphylactic reaction, hallucinations, intracranial hemorrhage, aseptic meningitis, taste loss, smell loss, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, hepatic failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruption, acute generalized pustular rash, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, female infertility, chest pain, heartburn, dry mouth, nausea, diarrhea, weakness, hypertriglyceridemia, hypercholesterolemia, transaminitis, increased ALT, increased AST, itching, leukopenia, neutropenia, chest discomfort

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Additionally, when storing the medication, it is important to maintain a room temperature between 1 degree Celsius to 30 degrees Celsius. This ensures the medication's efficacy and safety is preserved for a long time.

Appearance

Yellow, rectangular, film-coated tablets consisting of two layers

Package unit

30 tablets/bottle, 300 tablets/bottle