Rexduo Tablets

Adult dose

Adults: Take 1 tablet twice daily. This medicine may be taken with or without food. Swallow this medicine whole; do not crush or split it. ○ Patients with hepatic impairment Use of this medicine is not recommended when initiating treatment in patients with hepatic impairment who require a dose reduction (see 5. General precautions under Precautions for use).

This medication should be discussed with a doctor or pharmacist if taken by individuals who regularly consume more than three alcoholic beverages a day, as it may lead to serious side effects such as gastrointestinal bleeding. This medication may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, so it should only be used in the minimal dosage for the shortest duration; even in the absence of a history of cardiovascular disease, symptoms should be monitored carefully. This medication may cause serious gastrointestinal adverse reactions such as perforation, ulcers, and bleeding, so particularly elderly patients or those with a history of gastrointestinal diseases should closely monitor for gastrointestinal symptoms during use and consult healthcare professionals immediately if any unusual symptoms occur. This medication should not be administered to patients with specific allergic reactions or hypersensitivity, severe heart, liver, or kidney diseases, those with active peptic ulcers, women who are pregnant or may become pregnant, and nursing mothers. Patients with impaired liver or kidney function, asthma, or hypertension should consult their doctor thoroughly before taking this medication and use it cautiously. This medication may cause various adverse reactions, including dyspepsia, headaches, skin rashes, edema, liver function abnormalities, and hypertension; therefore, any unusual symptoms should be reported to a healthcare professional immediately during use. Since this medication is metabolized in the liver, there may be interactions with other medications, particularly when taken with drugs that inhibit or induce liver enzymes, requiring dosage adjustment and monitoring. Women who are pregnant or planning to become pregnant should avoid using this medication, and nursing mothers should consult a specialist before taking it. Elderly patients may have decreased kidney, liver, and heart function, necessitating greater caution when using this medication, and dosage adjustments may be required. Regular blood tests and liver and kidney function checks should be conducted during the use of this medication to monitor for any abnormalities; if any abnormal findings arise, usage should be discontinued immediately. In cases of overdose, symptoms may include nausea, vomiting, drowsiness, and lethargy; severe cases may result in gastrointestinal bleeding, renal failure, and respiratory depression, requiring immediate emergency treatment. This medication should be stored out of the reach of children, and transferring it to another container may lead to a decrease in quality, so caution is advised.

Gastrointestinal bleeding, cardiovascular thrombotic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, dyspepsia, nausea, upper abdominal pain, constipation, diarrhea, dry mouth, esophageal pain, stomatitis, COVID-19, acute pyelonephritis, facial edema, pain at the site of insertion, peripheral edema, fever, pruritus, psoriasis, rash, skin swelling, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated blood pressure, elevated serum uric acid, elevated gamma-glutamyl transferase, arthralgia, back pain, coccygodynia, flank pain, headache, carpal tunnel syndrome, lymphadenopathy, cholelithiasis, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confused state, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, distension, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, urticaria, angioedema, alopecia, blistering dermatitis, peripheral edema, influenza-like illness, injury, vesicular dermatitis, petechial hemorrhage, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, menstrual disorders, female infertility, chest pain, heartburn, dry mouth, weakness, hypertriglyceridemia, hypercholesterolemia, transaminitis, elevated ALT, elevated AST, leukopenia, neutropenia, blurred vision, upper abdominal pain, epigastric discomfort, non-food related epigastric pain, insomnia, thirst, ulcerative stomatitis, allergy, low back pain, hyperlipidemia, diabetes, weight gain, fracture, arthralgia, RA factor positive, herpes zoster, pneumonia, dyspnea, hearing loss, headache, dizziness, constipation, gastritis, urticaria, anemia, vomiting, exacerbation of gastrointestinal inflammation, angular cheilitis, intestinal obstruction, intestinal perforation, hemorrhagic colitis, esophageal perforation, bowel obstruction, alveolar osteitis post tooth extraction, enteric ulcer, melena, stomatitis, aphthous stomatitis, oral mucosal vesiculation, numbness of the mouth, oral pain, leg cramps, tension, altered sensation, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, exacerbation of allergy, weakness, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic reaction, angioedema, insomnia, loss of appetite, increased appetite, depression, neuroexcitability, drowsiness, fatal intracranial hemorrhage, hallucinations, epilepsy exacerbation, upper respiratory tract infection, sinusitis, pharyngitis, bronchitis, bronchospasm, exacerbated bronchospasm, dyspnea, laryngitis, pneumonia, epistaxis, voice disorders, vesicular dermatitis, petechial hemorrhage, rash, alopecia, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, maculopapular rash, skin dryness, increased sweating, urticaria, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash associated with eosinophilia and systemic symptoms, vasculitis, contact dermatitis, injection site reaction, skin nodules, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, visual confusion, cataract, conjunctivitis, ocular pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, elevated β2-microglobulin, elevated NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, heartburn, dry mouth, nausea, diarrhea, facial edema, generalized edema, weakness, hypertriglyceridemia, hypercholesterolemia, transaminitis, elevated ALT, elevated AST, itching, leukopenia, neutropenia, chest discomfort, headache, upper respiratory tract infection, blurred vision, urticaria, gastritis, abdominal pain, gastroesophageal reflux, epigastric discomfort, non-food related epigastric pain, insomnia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Yellow oblong film-coated tablet consisting of two layers

Package unit

30 tablets/bottle, 300 tablets/bottle