Cox2Plus Tablets

Adult dose

Adults: Take 1 tablet twice daily. This medicine may be taken with or without food. Swallow this medicine whole; do not crush or split it. ○ Patients with hepatic impairment Use of this medicine is not recommended when initiating treatment in patients with hepatic impairment who require a dose reduction (see 5. General precautions under Precautions for use).

This medication should be consulted with a doctor or pharmacist before use for individuals who consume more than three drinks daily on a regular basis. There is a risk of gastrointestinal bleeding if heavy drinkers take this medication. This drug can lead to cardiovascular problems and increase the risk of serious thrombotic events such as myocardial infarction or stroke. This risk may increase depending on the dosage and duration of use, so it is important to use the minimum effective dose for the shortest duration possible. Even in patients without a history of cardiovascular disease, it is crucial to monitor for symptoms such as chest pain, shortness of breath, weakness, or slurred speech, and to take immediate action if they occur. Gastrointestinal side effects can include perforation, ulceration, and bleeding in the stomach or intestines. Particularly, elderly patients or those with a history of gastrointestinal disease should be extra cautious; if they experience symptoms such as epigastric pain, dyspepsia, black stools, or hematemesis during treatment, they should visit a medical facility immediately. This drug should not be used by individuals with known allergy responses, severe heart, liver or kidney dysfunction, active peptic ulcers or inflammatory bowel disease, or by pregnant or nursing women. Patients with compromised liver or kidney function, asthma, heart failure, hypertension, or a history of edema should be particularly cautious when taking this medication and should regularly monitor their health condition during treatment. Side effects during treatment may include headache, dyspepsia, nausea, diarrhea, rash, and edema. If severe skin rashes or allergic reactions occur, the medication should be stopped immediately and a healthcare professional consulted. This medication can interact with other drugs, particularly when taken with blood pressure medications, diuretics, anticoagulants, or antidepressants; consultation with a doctor is advised. Also, women who are pregnant or planning to become pregnant should consult their healthcare provider before taking this medication, and it should be stopped immediately if pregnancy is confirmed during treatment. The elderly may have decreased kidney and liver function, so close monitoring during treatment is recommended, starting with the lowest effective dose. Finally, this medication may cause dizziness or drowsiness, so it is advisable to avoid driving or operating machinery.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, upper and lower gastrointestinal perforations, ulcers, bleeding, dyspepsia, nausea, epigastric pain, constipation, diarrhea, dry mouth, esophageal pain, stomatitis, COVID-19, acute pyelonephritis, facial edema, pain at the site of insertion, peripheral edema, fever, pruritus, psoriasis, rash, skin swelling, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated blood pressure, increased uric acid in the blood, elevated gamma-glutamyl transferase, arthralgia, back pain, coccygodynia, flank pain, headache, carpal tunnel syndrome, lymphadenopathy, cholecystitis, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, distension, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, itching, urticaria, angioedema, alopecia, vesicular dermatitis, peripheral edema, influenza-like illness, injury, breast pain, menopausal symptoms, fibrocystic breast disease, chest pain, dysmenorrhea, menstrual disorder, vaginal bleeding, vulvovaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, abnormal liver function, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased sodium in the blood, increased potassium in the blood, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, osteoarthritis, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendonitis, myositis, leg cramps, fractures, tendon rupture, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, pyoderma, contact dermatitis, skin nodules, taste disturbance, albuminuria, hematuria, dysuria, pollakiuria, nephrolithiasis, incontinence, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased creatinine in the blood, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, breast pain, heartburn, dry mouth, nausea, diarrhea, fatigue, hypertriglyceridemia, hypercholesterolemia, transaminitis, increased ALT, increased AST, itching, leukopenia, neutropenia, chest discomfort, blurred vision, epigastric discomfort, gastroesophageal reflux, insomnia, epigastric pain not related to food, allergic reaction, weakness, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, urticaria, alopecia, dermatitis, nail disorders, photosensitivity reaction, erythematous rash, maculopapular rash, skin dryness, increased perspiration, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, headache, dizziness, leg cramps, muscle tension, sensory decrease, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, olfactory loss, ageusia, back pain, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, peripheral edema, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, urticaria, alopecia, dermatitis, nail disorders, photosensitivity reaction, erythematous rash, maculopapular rash, skin dryness, increased perspiration, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, pyoderma, contact dermatitis, skin nodules, taste disturbance, albuminuria, cystitis, hematuria, dysuria, pollakiuria, nephrolithiasis, incontinence, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased creatinine in the blood, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, female infertility, chest pain, heartburn, dry mouth, nausea, diarrhea, fatigue, hypertriglyceridemia, hypercholesterolemia, transaminitis, increased ALT, increased AST, itching, leukopenia, neutropenia, chest discomfort, blurred vision, epigastric discomfort, gastroesophageal reflux, insomnia, epigastric pain not related to food, allergic reaction, weakness, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, urticaria, alopecia, dermatitis, nail disorders, photosensitivity reaction, erythematous rash, maculopapular rash, skin dryness, increased perspiration, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, headache, dizziness, leg cramps, muscle tension, sensory decrease, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, olfactory loss, ageusia, back pain, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, peripheral edema, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is best to keep the storage temperature between 1 to 30 degrees Celsius to maintain the medication's efficacy and safety over time.

Appearance

A yellow rectangular film-coated tablet consisting of two layers.

Package unit

30 tablets/bottle, 300 tablets/bottle