Empaganduo Tablets 12.5/500 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage for this medication is 1 tablet once in the morning and once in the evening. Dosage is determined considering each patient's current treatment regimen, efficacy, and tolerability within the maximum recommended daily doses of 25 mg of Empagliflozin and 2000 mg of Metformin. - For patients unable to achieve adequate blood sugar control with Metformin alone or in combination with insulin or other medications, the recommended dosage is 5 mg of Empagliflozin twice a day.

This medication may cause severe lactic acidosis; therefore, it should not be used by patients with renal impairment, severe infections, dehydration, or acute cardiac conditions. Additionally, it is not recommended for type 1 diabetes patients or those with a history of lactic acidosis. Care should be taken as hypoglycemia may occur when used with insulin or sulfonylureas. This medication should be temporarily discontinued before and after tests involving iodinated contrast agents, and should only be resumed once renal function is confirmed normal. It is safest for pregnant or breastfeeding women not to take this medication. Elderly patients or those with renal impairment should have regular monitoring of renal function and dosage adjustments if needed. If dehydration or gastrointestinal disturbances occur during treatment, immediate consultation with a healthcare provider is necessary, and in cases of severe fluid loss, temporary cessation of medication may be needed. There is a risk of vitamin B12 deficiency, so monitoring serum vitamin B12 levels during prolonged use is advised. Hypoglycemia symptoms may appear, so do not skip meals and monitor blood sugar levels closely after vigorous exercise. This medication may increase the risk of genital and urinary tract infections, so prompt treatment is required if related symptoms occur. If pain, swelling, or redness around the genital area occurs during medication, inform the healthcare provider immediately. In cases where food intake is not possible for a long period due to surgery or significant illness, temporary discontinuation of this medication may be necessary. In case of overdose, treatments like dialysis may be required, making adherence to the prescribed dosage important. It is advised to avoid alcohol while taking this medication, and consult with healthcare providers if taking other medications that may interact.

Serious side effects

• Hives
• angioedema
• necrosis of the perineum
• ketoacidosis
• lactic acidosis
• severe rash with high fever
• blistering
• peeling skin
• pain in the mouth/eyes
• severe swelling

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• altered taste
• itching
• rash
• erythema

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain storage temperatures between 1 degree and 30 degrees Celsius at room temperature to ensure prolonged safety and effectiveness.

Appearance

Biconvex oval film-coated tablets with a light brownish purple color

Package unit

60 tablets/box [10 tablets/PTP x 6], 10 tablets/box [10 tablets/PTP x 1], 30 tablets/bottle, 60 tablets/bottle