Januglugem Tablets 50/850 mg (Sitagliptin Hydrochloride Monohydrate/Metformin Hydrochloride)

Adult dose

In diabetes therapy, the dosage should be determined within the limits of not exceeding 100 mg of sitagliptin and 2000 mg of metformin, considering the patient's treatment regimen, efficacy, and tolerance. Generally, take this medication twice a day with meals, and gradually increase the dosage to reduce gastrointestinal adverse reactions. The initial dosage may vary based on the patient's current treatment regimen. 1. For patients with no prior experience with metformin treatment: Januglugem 50/500 mg.

This medication contains sitagliptin and metformin components and is used for diabetes treatment. First, during the use of this medication, there is a possibility of serious allergic reactions, so if symptoms such as skin rash, hives, or difficulty breathing occur, one must immediately stop taking the medication and consult a physician. Additionally, this medication carries a risk of acute pancreatitis, which causes inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, or vomiting appear, one must inform medical personnel immediately. Due to the metformin component, there is a rare but fatal condition known as lactic acidosis that may occur, thus, if sudden fatigue, muscle pain, difficulty breathing, or abdominal pain are suspected, one must go to the hospital immediately. Patients with impaired kidney function, severe liver disease, heart failure, dehydration, or severe infections should not take this medication, and especially when undergoing tests that require iodine contrast agents, the use of this medication should be temporarily suspended. It is safest for pregnant or breastfeeding women and children under 18 years old not to use this medication. While taking it, one should be cautious of symptoms of hypoglycemia, especially when taken in conjunction with other blood sugar-lowering agents as more caution is needed. Symptoms of hypoglycemia may include dizziness, cold sweat, and severe hunger. The risk may increase when this medication is taken with alcohol, so it is advisable to avoid drinking. Moreover, as this medication includes specific dyes, those allergic to these dyes should take it with caution. During treatment, regular blood tests and kidney function tests should be conducted, and if any abnormal symptoms occur, one should inform medical personnel immediately. If a surgery is to be performed, the medication should be discontinued 48 hours prior to the surgery, and after recovery, it should be resumed only after confirming normal kidney function. Lastly, this medication can also be administered to the elderly, but monitoring kidney function frequently and adjusting the dosage may be necessary.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain (severe skin adverse reaction), pancreatitis, acute pancreatitis, acute renal failure, shortness of breath or difficulty breathing, asthma attack, cough with fever accompanied respiratory abnormalities, skin or eyes turning yellow (jaundice), extreme lethargy

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a sealed container to avoid contact with air. The appropriate storage temperature is between 1 to 30 degrees Celsius at room temperature, and it is important to avoid extremely hot or cold places.

Appearance

Pink oval film-coated tablet

Package unit

Bottle - 100 tablets/bottle, Bottle - 30 tablets/bottle