Sitaone Plus Tablet 50/500 mg (Sitagliptin, Metformin)

Adult dose

The usual oral dosage for this medication is twice a day with meals, and to minimize gastrointestinal adverse reactions caused by metformin, the dosage should be gradually increased. The initial dosage varies based on the patient’s current treatment regimen. 1. For patients not treated with metformin: - Take this medication 50/500 mg twice a day, 1 tablet per dose. - For escalation, 50/1000 mg twice a day, 1 tablet per dose. 2. For patients receiving metformin

This medication contains sitagliptin and metformin, which are diabetes treatments that help control blood sugar. First, serious hypersensitivity reactions may occur while taking this medication; therefore, if symptoms such as skin rash, itching, or difficulty breathing appear, stop taking it immediately and consult a doctor. Additionally, this medication can cause acute pancreatitis, a serious inflammation of the pancreas, so symptoms like abdominal pain, nausea, vomiting, or fever should be reported to medical staff immediately. The metformin component can rarely cause lactic acidosis, a serious metabolic disturbance. If sudden fatigue, muscle pain, difficulty breathing, abdominal pain, or changes in consciousness occur, visit the hospital immediately. Patients with reduced kidney function, severe infections or dehydration, acute heart failure, or myocardial infarction should not take this medication. If undergoing tests using iodine contrast agents, this medication should be stopped for some time before and after the test. Pregnant women or women with a possibility of pregnancy, as well as nursing mothers, should not take this medication. This medication can cause hypoglycemia, so caution is needed, especially if meals are skipped or irregular, when engaging in intense exercise, or when taken with other blood sugar-lowering agents. Regular kidney function and blood tests are recommended, and vitamin B12 levels should be checked periodically. Alcohol consumption can increase the risk of side effects from this medication, so excessive drinking should be avoided during use. If surgery is planned or in cases of severe illness, temporarily discontinuing this medication may be necessary, and it can be resumed once the condition stabilizes. Lastly, if any unusual symptoms such as sudden joint pain or skin blisters occur while taking this medication, consult a doctor immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, rash, severe allergic reactions, cutaneous vasculitis, Stevens-Johnson syndrome, severe skin adverse reactions, blisters, skin peeling, pain in oral and ocular mucosa, acute pancreatitis, acute kidney failure, dyspnea, unstable angina, severe hypoglycemia, severe edema accompanied by increased blood pressure, elevated liver enzymes, jaundice, severe headache,

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• headache
• upper respiratory infection
• nasopharyngitis
• constipation
• weakness
• muscle pain

Store this medication in a tightly sealed container to prevent exposure to air or moisture, and keep it at a temperature between 1 and 30 degrees Celsius. This storage will help maintain the medication's effectiveness and prevent deterioration.

Appearance

Bright pink oval film-coated tablets

Package unit

56 tablets/box [(14 tablets/PTP x 4)], 30 tablets/bottle, 200 tablets/bottle