Rabe Duet Tablets 20/500 mg

Adult dose

1) Gastric ulcer, duodenal ulcer: 10/500 mg is administered orally once daily. Depending on symptoms, 20/500 mg may be administered orally once daily. Treatment duration is up to 8 weeks for gastric ulcers and 6 weeks for duodenal ulcers. 2) Erosive or ulcerative gastroesophageal reflux disease: 10/500 mg or 20/500 mg is administered once daily for 4 to 8 weeks. If there is no improvement after 8 weeks of treatment, it can be continued for another 8 weeks.

Child dose

Safety in children has not been established.

This medication should not be used by patients with a hypersensitivity to this drug or any of its components, or to benzimidazole derivatives. Also, patients taking certain medications such as atazanavir or rilpivirine should not take this drug, and women who are pregnant or breastfeeding should refrain from using this medication. Patients with impaired liver or kidney function, elderly patients, or those with heart or lung disease should be very cautious when using this medication. In particular, patients with severe gastrointestinal ulcers or electrolyte imbalances, as well as those who need to limit sodium intake, require special attention. This medication may have various side effects, and allergic reactions such as skin rashes or itching may occur, so it is important to discontinue use immediately if such symptoms appear. Abnormal blood-related issues, liver function abnormalities, cardiovascular problems, and gastrointestinal symptoms may arise, so regular blood tests and liver function tests are necessary. Central nervous system symptoms such as headaches, dizziness, insomnia, and depression have also been reported, and various adverse reactions may occur in the respiratory, musculoskeletal, and urinary systems. This medication inhibits gastric acid secretion, so long-term use may increase the risk of fractures and may lead to electrolyte abnormalities such as hypomagnesemia, hence regular blood tests are necessary. Additionally, decreased gastric acidity may increase the risk of gastrointestinal infections, so if diarrhea symptoms persist, consultation with healthcare professionals is advised. This medication does not significantly impact driving or operating machinery; however, caution is needed as drowsiness may occur. There may be interactions with specific medications, so it is essential to inform healthcare professionals if other medications are being taken. Women who are pregnant or breastfeeding should not use this medication, and elderly patients may experience more pronounced side effects due to reduced liver function, thus care should be taken. Safety in children has not been established, and its use is not recommended. There is no specific antidote for overdose, and treatment and supportive care according to symptoms are needed. This medication should be swallowed whole without chewing or crushing the tablets and kept out of reach of children. Long-term use may increase the risk of gastric polyps, so the lowest effective dose and shortest duration of treatment are recommended. If any unusual symptoms occur during the course of this medication, it is important to consult with healthcare professionals immediately for appropriate action.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, liver abnormalities (jaundice), severe skin reactions (severe rash, blistering, skin peeling, oral/ocular mucosal pain), severe neurological symptoms (severe headaches, thunderclap headaches, seizures, altered consciousness, visual disturbances, paralysis), severe swelling or urination abnormalities (decreased urine output, generalized severe edema, elevated blood pressure), systemic allergic reactions (hypotension, dyspnea, facial swelling), toxic

Mild side effects

Rash, itching, blood abnormalities (decreased red blood cells, decreased white blood cells, increased white blood cells, increased eosinophils, increased neutrophils, decreased lymphocytes, anemia, petechiae, lymphadenopathy, hypochromic anemia, pancytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia), elevated ALT/AST/ALP/γ-GTP/LDH/total bilirubin, hypertension, myocardial infarction, abnormal ECG, migraine, syncope, angina, arrhythmia, palpitations, bradycardia, tachycardia

This medication should be kept in a tightly closed container to protect it from air and moisture. Additionally, it is best stored at room temperature between 1 and 30 degrees Celsius.

Appearance

Brownish-yellow oval film-coated tablets

Package unit

28 tablets per bottle