Rabeol Duo Tablet 20/500 mg

Adult dose

1. Gastric ulcer, duodenal ulcer: A usual dose of 10/500mg is administered orally once daily. Depending on symptoms, 20/500mg may be administered orally once daily. The duration of treatment is typically 8 weeks for gastric ulcers and 6 weeks for duodenal ulcers. 2. Erosive or ulcerative gastroesophageal reflux disease: 10/500mg or 20/500mg is administered orally once daily for 4–8 weeks. If symptoms are not resolved, an additional 8 weeks of 10/500mg or 20/500mg may be given twice daily orally. However, dosing 20/500mg twice daily is restricted to patients with confirmed severe mucosal damage. 3. Symptom relief for gastroesophageal reflux disease: 10/500mg is administered once daily. If symptoms do not control after 4 weeks, additional medical evaluation is needed. Once symptoms have resolved, on-demand therapy with 10/500mg taken once daily may be used to manage subsequently arising symptoms. 4. Long-term maintenance therapy for gastroesophageal reflux disease: Patients may be prescribed 10/500mg or 20/500mg orally once daily, depending on individual needs. 2. Patients with liver impairment: Adverse reactions of hepatic encephalopathy have been reported in patients with cirrhosis, thus caution is advised in administration. 3. The elderly: Caution is advised as there are often declining liver functions. 4. Pediatric patients: Safety in children has not been established.

Child dose

Safety for children has not been established.

This drug should not be used by certain patients. Patients allergic to this drug or its components, those who have experienced hypersensitivity, and those taking Atazanavir or Rilpivirine, as well as pregnant or nursing women should not take this drug. Patients with poor liver function, the elderly, those with a history of drug allergies, severe gastrointestinal ulcers, impaired kidney function, heart or lung dysfunction, electrolyte imbalances, certain kidney diseases, and patients who need to limit sodium intake should take this drug with caution and be monitored closely by a physician. This drug suppresses gastric acid secretion and may cause various side effects. If allergic reactions such as skin rashes or itching occur, discontinue use immediately. Regular blood tests are required as there may be changes in red or white blood cell counts. Liver function tests are also necessary, and if liver function abnormalities occur, the medication should be discontinued. Symptoms or signs related to the heart may also arise, necessitating caution. Gastrointestinal symptoms could include diarrhea, abdominal pain, nausea, and vomiting; in severe cases, serious conditions such as hepatic encephalopathy or pancreatitis could occur, so if symptoms are severe, consult a doctor immediately. Symptoms affecting the central nervous system may include headaches, dizziness, insomnia, drowsiness, and depression, and rarely severe symptoms such as confusion or seizures can occur. Respiratory symptoms may include coughing and shortness of breath; if dangerous conditions like interstitial pneumonia arise, discontinue use immediately and go to the hospital. Myalgia or arthralgia has also been reported, and skin-related side effects may include hair loss, skin rashes, and in severe cases, serious skin reactions such as Stevens-Johnson syndrome. This drug may cause eye problems, so if visual disturbances or pain occur, inform a doctor. Urinary symptoms may include difficulty urinating and hematuria, warranting medical attention if abnormal symptoms arise. Additionally, systemic symptoms such as edema, weight gain, and fatigue may occur. This drug contains sodium bicarbonate, which may lead to alkalosis or sodium retention edema, so careful monitoring is necessary. This drug may obscure malignant tumor symptoms or delay diagnosis; thus, it should only be administered after confirming malignancy in patients with gastric ulcer symptoms accompanied by weight loss, recurrent vomiting, hematemesis, or melena. Regular check-ups are necessary for long-term usage, especially for those taking it for over a year. It is advisable to periodically undergo blood and liver function tests during administration, and consult a doctor immediately if abnormal symptoms appear. This drug may increase the risk of fractures related to osteoporosis, so caution regarding bone health is needed for long-term use. Additionally, hypomagnesemia may occur, so magnesium levels should be regularly checked when taking it long-term or alongside certain medications. This drug may promote bacterial growth in the gastrointestinal tract by suppressing gastric acid secretion, increasing the risk of infectious diarrhea; report any persistent diarrhea symptoms to healthcare providers. Driving or operating machinery may cause drowsiness, so caution is advised. There may be interactions with other medications, so consult a doctor especially when taking with Warfarin, Methotrexate, Atazanavir, or Rilpivirine. Pregnant or nursing women should not take this drug, and those planning to become pregnant or who are pregnant should consult a physician. Elderly patients may experience adverse reactions due to declining liver function, so any symptoms should be reported immediately to a doctor, and the medication should be discontinued as necessary. Safety in children has not been established, so it is advisable not to administer this drug to them. This drug should not be chewed or crushed, but taken whole in tablet form, and stored out of reach of children. In case of overdose, there is no specific antidote, so appropriate treatment should be administered according to symptoms, under medical guidance.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction)
• High fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa (severe skin abnormal reactions)
• Shortness of breath or difficulty breathing, asthma attacks, breathing difficulties accompanied by cough and fever (respiratory problems)
• Skin or eyes turning yellow (jaundice), extreme lethargy (liver dysfunction)
• Sudden and very severe headache

Mild side effects

Possible side effects that may appear occasionally include rash, hives, itching, diarrhea, constipation, abdominal pain, abdominal bloating, dyspepsia, burping, nausea, dry mouth, vomiting, taste disturbances, headache, insomnia, anxiety, dizziness, drowsiness, cough, nosebleeds, pharyngitis, rhinitis, sweating, alopecia, arthralgia, myalgia, chest discomfort, edema, hypertension, palpitations, hematochezia, oral ulcers, dysphagia, gingivitis, cholelithiasis, pancreatitis, skin discoloration, eye pain,

This drug should be stored in a sealed container to prevent air or moisture exposure, at a temperature between 1 degree to 30 degrees Celsius. Storing it in this manner helps maintain the drug's efficacy and prevents degradation.

Appearance

Brownish-yellow oval film-coated tablet

Package unit

28 tablets/bottle