Danubia Tablet 100 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg either as monotherapy or in combination, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with renal impairment, - For mild to moderate renal impairment (eGFR 45 to less than 90), dose adjustment is not necessary. - In moderate renal impairment with a glomerular filtration rate (GFR) of 30 to less than 45, the dose is 50 mg once daily. -

This medication can rarely cause serious allergic reactions; hence, if symptoms such as skin rash or difficulty breathing occur, immediate discontinuation and consultation with a physician is required. During treatment with this medication, serious pancreatic inflammation known as pancreatitis may occur, so if symptoms like abdominal pain, vomiting, or loss of appetite arise, you should notify medical personnel immediately. This medication should not be used by patients with type 1 diabetes or those suffering from diabetic ketoacidosis, and it should also be avoided if there is an allergy to this medication or its components. Patients with impaired renal function should have their dosage adjusted, making it important to determine the appropriate dose through kidney function tests. When used in combination with other diabetes medications, this medication may increase the risk of hypoglycemia; therefore, blood sugar levels should be carefully monitored when taken with insulin or sulfonylureas. If severe joint pain or blistering skin symptoms appear, the medication should be discontinued immediately, and consultation with a specialist is advised. The use of this medication is not recommended for pregnant or breastfeeding women, and its safety and efficacy have not been established in children under 18 years of age. Elderly patients may have decreased kidney function, so evaluating and monitoring kidney function before starting this medication is necessary. In case of overdose, immediate medical attention should be sought, and this medication can be partially removed through hemodialysis. If any adverse reactions or discomfort occur while taking this medication, it is crucial to consult medical personnel to receive appropriate measures.

Serious side effects

• Hives
• angioedema
• chest tightness
• difficulty breathing
• cold sweat
• pallor
• anaphylaxis
• severe hypersensitivity reactions
• Stevens-Johnson syndrome
• exfoliative skin disease

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a sealed container to prevent air or moisture ingress. It is advisable to maintain the storage temperature between 1 to 30 degrees Celsius to ensure the medication's efficacy and safety.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle