Sitagliptin Hydrochloride Hydrate Tablets 100 mg

Adult dose

This medication is administered once daily at a dosage of 100 mg for both monotherapy and combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dosage adjustment is required based on kidney function. For mild to moderate renal impairment (eGFR between 45 and 90), no dosage adjustment is necessary.

This medication can cause serious allergic reactions, although rarely. These reactions may include anaphylaxis, swelling of the face or neck, and severe skin disorders. Such symptoms may occur within the first three months after starting the medication, so caution is needed. This medication may cause inflammation of the pancreas, known as acute pancreatitis, so if symptoms of pancreatitis occur, the medication should be discontinued immediately. Symptoms of pancreatitis include severe abdominal pain, vomiting, and nausea. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should not be given to individuals allergic to this medication or its components. Patients with impaired kidney function may have delayed excretion of this medication, so dosage adjustment is necessary, and regular kidney function tests are important. While taking this medication, side effects such as cold-like symptoms, headache, indigestion, and diarrhea may occur. Additionally, if taken together with insulin or sulfonylureas, the risk of hypoglycemia may increase, so thorough blood sugar management is essential. If severe joint pain or skin blistering symptoms occur, it is important to consult a doctor immediately, and discontinuation of the medication may be necessary. It is advisable for pregnant or breastfeeding women not to take this medication, and safety in children or adolescents under 18 years of age has not been fully established. In case of overdose, immediate medical attention should be sought, and this medication can be partially removed through dialysis if needed. There is also a potential for drug interactions while taking this medication, so it's important to consult a doctor or pharmacist about all medications being taken.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute pancreatitis, severe and disabling joint pain, blistering dermatitis, liver abnormalities due to increased liver enzymes (including jaundice symptoms), acute renal failure, cardiac arrest, pneumonia, diabetes complications, metabolic acidosis, severe allergic reactions, angioedema, difficulty breathing, thrombocytopenia, rhabdomyolysis

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• itching

This medication should be stored in a sealed container to prevent air from entering, and it is best kept at room temperature between 1 to 30 degrees Celsius. This will help maintain the effectiveness of the medication and prevent degradation.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle