Janumet 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

The recommended dose is 100 mg once daily for either monotherapy or in combination therapy, with a maximum daily dose of 100 mg. For patients with moderate renal impairment (glomerular filtration rate [eGFR] 30–45 mL/min/1.73 m2), the dose is reduced to 50 mg once daily. For patients with severe renal impairment (glomerular filtration rate [eGFR] 15–30 mL/min/1.73 m2) or end-stage renal disease (glomerular filtration rate [eGFR] < 15 mL/min/1.73 m2), additional dose adjustments are made.

This medication may cause serious allergic reactions such as skin rash, anaphylaxis, and angioedema, so caution is needed. If symptoms of pancreatitis, such as abdominal pain, vomiting, or persistent abdominal discomfort occur during the use of this medication, consult a healthcare professional immediately. It should not be used by patients with type 1 diabetes, diabetic ketoacidosis, or those with hypersensitivity to this medication or its components. Patients with impaired kidney function should have their dosage adjusted, and regular monitoring of kidney function is important. Low blood sugar symptoms may occur while using this medication; therefore, glucose levels should be carefully monitored, especially when taken with insulin or sulfonylureas. This medication may cause side effects such as headache, upper respiratory tract infections, nasopharyngitis, diarrhea, nausea, etc., so report to a healthcare professional if symptoms are severe. If severe joint pain or symptoms resembling bullous pemphigoid occurs, immediately discontinue use and consult a healthcare professional. Pregnant or nursing women should avoid taking this medication, and safety in children and adolescents under 18 years of age has not been established. In the event of overdose, seek appropriate treatment at a hospital immediately, as this medication can be partially removed through hemodialysis. This medication has minimal drug interactions, but consult a healthcare professional when used in conjunction with specific medications. Elderly patients may have a reduced kidney function, so dosage adjustments and regular kidney function assessments are necessary.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, rash, severe skin reactions (Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, difficulty breathing, severe hypoglycemia, severe joint pain, bullous pemphigoid, liver abnormalities (increased liver enzymes, jaundice), acute renal failure, severe neurological symptoms (including cardiac arrest)

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly sealed container to prevent air exposure and keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the drug's efficacy for a longer time.

Appearance

Pink, round, biconvex, film-coated tablet

Package unit

28 tablets/box [14 tablets/PTP×2]