Januglypta Tablets 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for both monotherapy and combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dosage adjustment is required depending on renal impairment. - In mild renal impairment (eGFR 60–90 mL/min/1.73 m²) and moderate renal impairment (eGFR 45–60 mL/min/1.73 m²), dosage adjustment is not necessary. - In moderate renal impairment

This medication may cause severe hypersensitivity reactions, so if allergic symptoms or skin abnormalities occur, discontinue use immediately and consult a physician. If symptoms of pancreatitis, such as severe abdominal pain, nausea, or vomiting occur while taking this medication, inform medical personnel immediately, and if pancreatitis is suspected, discontinue use of this drug. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, and it should not be administered to individuals who are allergic to this drug or its components. Patients with impaired kidney function need to adjust their dosage, so regular kidney function tests should be conducted, and the medication should be taken according to a physician's instructions. This medication can cause hypoglycemia, so when used in combination with insulin or sulfonylurea, blood sugar levels should be carefully monitored, and dose adjustments for hypoglycemic agents may be necessary. Symptoms such as headache, upper respiratory infection, nasopharyngitis, diarrhea, etc., may occur during treatment; consult medical personnel if the symptoms persist or worsen. This medication can be used in the elderly, but dosage adjustments and kidney function tests are essential due to possible decreased kidney function. Pregnant or breastfeeding women should avoid this medication, and safety and efficacy have not been established in children and adolescents under 18 years of age. In cases of overdose, it is necessary to remove the drug from the gastrointestinal tract and provide appropriate treatment and monitoring, such as an electrocardiogram; some may be removed by dialysis. If symptoms like joint pain, skin blisters, or rash occur during treatment, inform a doctor immediately, and if necessary, drug discontinuation and specialist evaluation may be required. Drug interactions are minimal, but caution is advised when taken with cyclosporine or digoxin, and consultation with a physician is recommended before taking them.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, anaphylaxis, angioedema, rash, severe skin reactions such as Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, severe and debilitating joint pain, blistering-like pemphigoid, pneumonia, diabetes complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

Store this medication in a tightly closed container that is well-ventilated. It is important to maintain a storage temperature between 1°C and 30°C room temperature. Proper storage will help preserve the effectiveness of the medication for a longer period.

Appearance

Light apricot-colored, round, double-sided, convex film-coated tablets

Package unit

PTP - 28 tablets/box [(14 tablets/PTP×2)], bottle - 30 tablets/bottle, bottle - 90 tablets/bottle