Ramset Freefield Injection (Ramosetron Hydrochloride)

Adult dosage

Administer 0.3 mg intravenously once daily as Ramosetron Hydrochloride. If the effect is insufficient, the same dose may be administered again. However, do not exceed a total daily dose of 0.6 mg. Adjust according to symptoms as appropriate.

This medication should not be used in patients with a known allergy to this drug or any of its components. Use caution in patients taking other serotonergic medications, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Rarely, serious allergic reactions such as shock or anaphylaxis may occur; if symptoms appear, immediately discontinue administration and seek appropriate treatment. Additionally, this medication may cause seizure-like episodes similar to epilepsy, so caution is needed in patients with a history of epilepsy. Monitor symptoms as side effects such as headache, diarrhea, liver function abnormalities, rash, and itching may occur. This medication is primarily used to prevent nausea and vomiting caused by chemotherapy, and severe conditions known as serotonin syndrome may occur when used with other serotonergic drugs; therefore, close monitoring according to a doctor's instructions is essential. Caution is also necessary when taken with drugs that affect the enzymes that break down this medication in the liver, as this can increase blood concentration, raising the risk of side effects. Women who are pregnant or may become pregnant should carefully weigh the benefits and risks of using this medication, and it is recommended to discontinue breastfeeding if nursing. Safety in children has not been adequately established, so caution is needed when using in this population. Elderly patients may experience decreased physical function and should be carefully monitored during administration. This medication should not be mixed with certain intravenous solutions; caution is needed during preparation, and while it can be mixed with some intravenous solutions, it must be done according to professional guidance. Finally, animal studies have shown results indicating potential effects on the fetus, so special caution is warranted when used during pregnancy.

Serious side effects

Shock, symptoms resembling anaphylaxis (chest discomfort, difficulty breathing, asthma), seizure-like episodes resembling epilepsy

Mild side effects

Headache, feeling of heaviness in the head, rash, itching, redness, diarrhea, constipation, liver function abnormalities (increased AST, increased ALT, increased r-GTP, increased bilirubin), feeling of warmth, belching, heat in the head, tingling of the tongue

Store this medication in a tightly sealed container to prevent contact with air, preferably at room temperature between 1 and 30 degrees Celsius. Additionally, it should be kept in a dark place to protect it from light exposure to maintain its effectiveness.

Appearance

A colorless, clear liquid inside a glass vial sealed with rubber caps (part of the prefilled syringe system)

Package unit

6 prefilled syringes/box [2 mL/prefilled syringe × 6 ea]